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2.A.22.2.5 Gut epithelium absorptive neutral amino acid, K⁺- and Na⁺-dependent transporter KAAT1 (electrogenic; Cl^--dependent; activated by alkaline pH; all zwiterionic amino acids except methyl AIB are substrates). CAATCH1 is 95% identical to KAAT1. Leu > Thr and Pro.
Accession Number:	O76188
Protein Name:	KAAT1
Length:	634
Molecular Weight:	70239.00
Species:	Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm) [7130]
Number of TMSs:	12
Location¹ / Topology² / Orientation³:	Vacuole membrane¹ / Multi-pass membrane protein²
Substrate	sodium(1+), potassium(1+)

Pfam:	PF00209
Gene Ontology GO:0005887 C:integral to plasma membrane GO:0005328 F:neurotransmitter:sodium symporter activity GO:0006836 P:neurotransmitter transport
References (1) [1] “Cloning and characterization of a potassium-coupled amino acid transporter.” Castagna M.et.al. 9560287

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MNDGQVNGGF ESSEPKMEPK RSSQISLPPA NLKATMDNID DMDLEAEPPE RMVWSNNIEF 
61:	LMSCIATSVG LGNVWRFPFI AYQNGGGAFL VPYIIVLLLV GKPVYYLECV LGQFSSRNSV 
121:	KIWSISPAMK GTGYAQAVGC GYILSYYVVI CGLCLFYLAM SFQATLPWAI CQPEWENCVP 
181:	SDPTLAAGVG NITNGTSSAE LYFLRTVLQQ SDGIEGGLGA PIWYLVLCLF IAWLMVFGVV 
241:	ARGVKSSGKA AYFLALFPYV VMITLFITTV LLPGATDGIL FFVTPDWWKL LELGVWYAAI 
301:	TQVFFSLSVC TGAIIMFSSY NGFKQNVYRD ALIVTTLDTF TSFLSGCTIF GILGNLAYEL 
361:	NSDVGDVIGS GGTSLAFISY PDAIAKTFQP QLFSVLFFLM MSVLGIGSSV ALLSTLNTVV 
421:	MDAFPRVPTV YMSALSCTCG FLLGLVYCTP GGQFILELVD HYGGTFLVLF CAISELAGVF 
481:	WIYGLENLCL DIEFMMGKTT GFYWRLCWGI VTPGMMIIVF IYALLSFENL VFGDFYVYPV 
541:	AGYVAGYMML FLGIVLVPIG IVVTLYKYRT GNFRETVKKA FHSKPSWGPR SPRLRREWMQ 
601:	FRIEAKALRQ KMNTSRVKHL WYSITGAYRR NINK

2.A.22.2.5
Gut epithelium absorptive neutral amino acid, K⁺- and Na⁺-dependent transporter KAAT1 (electrogenic; Cl^--dependent; activated by alkaline pH; all zwiterionic amino acids except methyl AIB are substrates). CAATCH1 is 95% identical to KAAT1. Leu > Thr and Pro.

Cross database links:

Gene Ontology

References (1)

External Searches:

Analyze:

2.A.22.2.5Gut epithelium absorptive neutral amino acid, K+- and Na+-dependent transporter KAAT1 (electrogenic; Cl--dependent; activated by alkaline pH; all zwiterionic amino acids except methyl AIB are substrates). CAATCH1 is 95% identical to KAAT1. Leu > Thr and Pro.

Cross database links:

Gene Ontology

References (1)

External Searches:

Analyze:

2.A.22.2.5
Gut epithelium absorptive neutral amino acid, K⁺- and Na⁺-dependent transporter KAAT1 (electrogenic; Cl^--dependent; activated by alkaline pH; all zwiterionic amino acids except methyl AIB are substrates). CAATCH1 is 95% identical to KAAT1. Leu > Thr and Pro.