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Accession Number: | P48065 |
Protein Name: | NTBE aka SLC6A12 |
Length: | 614 |
Molecular Weight: | 69368.00 |
Species: | Homo sapiens (Human) [9606] |
Number of TMSs: | 11 |
Location1 / Topology2 / Orientation3: | Membrane1 / Multi-pass membrane protein2 |
Substrate | sodium(1+), glycine betaine, gamma-aminobutyric acid, sarcosine, N,N-dimethylglycine, proline, glycine, quinidine, 2,4-diaminobutyric acid |
Cross database links:
RefSeq: | NP_001116319.1 NP_001116320.1 NP_003035.3 |
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Entrez Gene ID: | 6539 |
Pfam: | PF00209 |
OMIM: |
603080 gene |
KEGG: | hsa:6539 hsa:6539 |
Gene Ontology
GO:0005887
C:integral to plasma membrane
GO:0005332
F:gamma-aminobutyric acid:sodium symporter ac...
GO:0005328
F:neurotransmitter:sodium symporter activity
GO:0006865
P:amino acid transport
GO:0006836
P:neurotransmitter transport
GO:0016021
C:integral to membrane
GO:0005886
C:plasma membrane
GO:0005332
F:gamma-aminobutyric acid:sodium symporter activity
GO:0071474
P:cellular hyperosmotic response
GO:0009992
P:cellular water homeostasis
GO:0006811
P:ion transport
GO:0007269
P:neurotransmitter secretion
GO:0010033
P:response to organic substance
GO:0055085
P:transmembrane transport
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References (10)[1] “Molecular cloning and functional characterization of a GABA/betaine transporter from human kidney.” Rasola A.et.al. 7589472 [2] “Cloning and expression of a betaine/GABA transporter from human brain.” Borden L.A.et.al. 7861179 [3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [4] “The finished DNA sequence of human chromosome 12.” Scherer S.E.et.al. 16541075 [5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [6] “Molecular cloning and functional characterization of a GABA/betaine transporter from human kidney.” Rasola A.et.al. 7589472 |
External Searches:
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Analyze:
Predict TMSs (Predict number of transmembrane segments) | ||||
FASTA formatted sequence |
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1: MDGKVAVQEC GPPAVSWVPE EGEKLDQEDE DQVKDRGQWT NKMEFVLSVA GEIIGLGNVW 61: RFPYLCYKNG GGAFFIPYFI FFFVCGIPVF FLEVALGQYT SQGSVTAWRK ICPLFQGIGL 121: ASVVIESYLN VYYIIILAWA LFYLFSSFTS ELPWTTCNNF WNTEHCTDFL NHSGAGTVTP 181: FENFTSPVME FWERRVLGIT SGIHDLGSLR WELALCLLLA WVICYFCIWK GVKSTGKVVY 241: FTATFPYLML VILLIRGVTL PGAYQGIIYY LKPDLFRLKD PQVWMDAGTQ IFFSFAICQG 301: CLTALGSYNK YHNNCYKDCI ALCFLNSATS FVAGFVVFSI LGFMSQEQGV PISEVAESGP 361: GLAFIAFPKA VTMMPLSQLW SCLFFIMLIF LGLDSQFVCV ECLVTASIDM FPRQLRKSGR 421: RELLILTIAV MCYLIGLFLV TEGGMYIFQL FDYYASSGIC LLFLSLFEVV CISWVYGADR 481: FYDNIEDMIG YRPWPLVKIS WLFLTPGLCL ATFLFSLSKY TPLKYNNVYV YPPWGYSIGW 541: FLALSSMVCV PLFVVITLLK TRGPFRKRLR QLITPDSSLP QPKQHPCLDG SAGRNFGPSP 601: TREGLIAGEK ETHL