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2.A.22.3.10 Sodium- and chloride-dependent GABA transporter 2 (GAT-2) (Solute carrier family 6 member 13). A deficiency of GAT-2 influences the metabolomics profile of Th1 cells, which provides insight into T cell responses to GAT-2 deficiency in mice (Ding et al. 2021).
Accession Number:	Q9NSD5
Protein Name:	Sodium- and chloride-dependent GABA transporter 2
Length:	602
Molecular Weight:	68009.00
Species:	Homo sapiens (Human) [9606]
Number of TMSs:	11
Location¹ / Topology² / Orientation³:	Membrane¹ / Multi-pass membrane protein²
Substrate	chloride, sodium(1+), gamma-aminobutyric acid

Entrez Gene ID:	6540
Pfam:	PF00209
KEGG:	hsa:6540
Gene Ontology GO:0005887 C:integral to plasma membrane GO:0005886 C:plasma membrane GO:0005332 F:gamma-aminobutyric acid:sodium symporter activity GO:0042165 F:neurotransmitter binding GO:0005328 F:neurotransmitter:sodium symporter activity GO:0007269 P:neurotransmitter secretion GO:0055085 P:transmembrane transport
References (5) [1] “Sequence and chromosomal assignment of a human novel cDNA: similarity to gamma-aminobutyric acid transporter.” Gong Y.et.al. 11824941 [2] “Cloning and characterization of a functional human gamma-aminobutyric acid (GABA) transporter, human GAT-2.” Christiansen B.et.al. 17502375 [3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [4] “The finished DNA sequence of human chromosome 12.” Scherer S.E.et.al. 16541075 [5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

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FASTA formatted sequence

1:	MDSRVSGTTS NGETKPVYPV MEKKEEDGTL ERGHWNNKME FVLSVAGEII GLGNVWRFPY 
61:	LCYKNGGGAF FIPYLVFLFT CGIPVFLLET ALGQYTSQGG VTAWRKICPI FEGIGYASQM 
121:	IVILLNVYYI IVLAWALFYL FSSFTIDLPW GGCYHEWNTE HCMEFQKTNG SLNGTSENAT 
181:	SPVIEFWERR VLKISDGIQH LGALRWELAL CLLLAWVICY FCIWKGVKST GKVVYFTATF 
241:	PYLMLVVLLI RGVTLPGAAQ GIQFYLYPNL TRLWDPQVWM DAGTQIFFSF AICLGCLTAL 
301:	GSYNKYHNNC YRDCIALCFL NSGTSFVAGF AIFSILGFMS QEQGVPISEV AESGPGLAFI 
361:	AYPRAVVMLP FSPLWACCFF FMVVLLGLDS QFVCVESLVT ALVDMYPHVF RKKNRREVLI 
421:	LGVSVVSFLV GLIMLTEGGM YVFQLFDYYA ASGMCLLFVA IFESLCVAWV YGAKRFYDNI 
481:	EDMIGYRPWP LIKYCWLFLT PAVCTATFLF SLIKYTPLTY NKKYTYPWWG DALGWLLALS 
541:	SMVCIPAWSL YRLGTLKGPF RERIRQLMCP AEDLPQRNPA GPSAPATPRT SLLRLTELES 
601:	HC

2.A.22.3.10
Sodium- and chloride-dependent GABA transporter 2 (GAT-2) (Solute carrier family 6 member 13). A deficiency of GAT-2 influences the metabolomics profile of Th1 cells, which provides insight into T cell responses to GAT-2 deficiency in mice (Ding et al. 2021).

Cross database links:

Gene Ontology

References (5)

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2.A.22.3.10Sodium- and chloride-dependent GABA transporter 2 (GAT-2) (Solute carrier family 6 member 13). A deficiency of GAT-2 influences the metabolomics profile of Th1 cells, which provides insight into T cell responses to GAT-2 deficiency in mice (Ding et al. 2021).

Cross database links:

Gene Ontology

References (5)

External Searches:

Analyze:

2.A.22.3.10
Sodium- and chloride-dependent GABA transporter 2 (GAT-2) (Solute carrier family 6 member 13). A deficiency of GAT-2 influences the metabolomics profile of Th1 cells, which provides insight into T cell responses to GAT-2 deficiency in mice (Ding et al. 2021).