Search TCDB: (?)
TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.22.3.11
Sodium- and chloride-dependent creatine transporter 1 (CT1 or CreaT) (Creatine transporter 1) (Solute carrier family 6 member 8, SLC6A8).  The bovine ortholog of the same size, a glycoprotein of about 210 - 230 Da, has been purified to near homogeneity (West et al. 2005). Cooperative Binding of Substrate and Ions Drives Forward Cycling of the Human CT-1. Creatine deficiency disorders have been reviewed (PMID 20301745). Transport of creatine metabolic precursors have also been discussed (Jomura et al. 2022), and the use of SLC6A8 for theraputic purposes has been considered (Kurth et al. 2021). The CreaT2 gene is expressed exclusively in the testes, but CreaT1 is expressed in a variety of tissues (Snow and Murphy 2001). CT1 is present in mouse kidney, skeletal muscle and brown adiose tissue, but not in the pancreas, and levels are suject to organ-specific regulation (Lygate et al. 2022).  Variants in GAMT, GATM and SLC6A8 for cerebral creatine deficiency syndromeshave been identified (Goldstein et al. 2024).

Accession Number:P48029
Protein Name:Sodium- and chloride-dependent creatine transporter 1
Length:635
Molecular Weight:70523.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate chloride, sodium(1+), creatine

Cross database links:

Entrez Gene ID: 6535   
Pfam: PF00209   
KEGG: hsa:6535   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005887 C:integral to plasma membrane
GO:0005886 C:plasma membrane
GO:0015220 F:choline transmembrane transporter activity
GO:0005309 F:creatine:sodium symporter activity
GO:0005328 F:neurotransmitter:sodium symporter activity
GO:0006600 P:creatine metabolic process
GO:0006936 P:muscle contraction

References (12)

[1] “Cloning, pharmacological characterization, and genomic localization of the human creatine transporter.”  Nash S.R.et.al.   7953292
[2] “The cloning and expression of a human creatine transporter.”  Sora I.et.al.   7945388
[3] “The genomic organization of a human creatine transporter (CRTR) gene located in Xq28.”  Sandoval N.et.al.   8661155
[4] “Cloning and sequencing of a cDNA encoding a novel member of the human brain GABA/noradrenaline neurotransmitter transporter family.”  Barnwell L.F.et.al.   7622069
[5] “Identification, characterization and cloning of SLC6A8C, a novel splice variant of the creatine transporter gene.”  Martinez-Munoz C.et.al.   18515020
[6] “The DNA sequence of the human X chromosome.”  Ross M.T.et.al.   15772651
[7] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[8] “Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.”  Daub H.et.al.   18691976
[9] “X-linked mental retardation with seizures and carrier manifestations is caused by a mutation in the creatine-transporter gene (SLC6A8) located in Xq28.”  Hahn K.A.et.al.   11898126
[10] “X-linked creatine deficiency syndrome: a novel mutation in creatine transporter gene SLC6A8.”  Bizzi A.et.al.   12210795
[11] “High prevalence of SLC6A8 deficiency in X-linked mental retardation.”  Rosenberg E.H.et.al.   15154114
[12] “High frequency of creatine deficiency syndromes in patients with unexplained mental retardation.”  Lion-Francois L.et.al.   17101918

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence 
1:	MAKKSAENGI YSVSGDEKKG PLIAPGPDGA PAKGDGPVGL GTPGGRLAVP PRETWTRQMD 
61:	FIMSCVGFAV GLGNVWRFPY LCYKNGGGVF LIPYVLIALV GGIPIFFLEI SLGQFMKAGS 
121:	INVWNICPLF KGLGYASMVI VFYCNTYYIM VLAWGFYYLV KSFTTTLPWA TCGHTWNTPD 
181:	CVEIFRHEDC ANASLANLTC DQLADRRSPV IEFWENKVLR LSGGLEVPGA LNWEVTLCLL 
241:	ACWVLVYFCV WKGVKSTGKI VYFTATFPYV VLVVLLVRGV LLPGALDGII YYLKPDWSKL 
301:	GSPQVWIDAG TQIFFSYAIG LGALTALGSY NRFNNNCYKD AIILALINSG TSFFAGFVVF 
361:	SILGFMAAEQ GVHISKVAES GPGLAFIAYP RAVTLMPVAP LWAALFFFML LLLGLDSQFV 
421:	GVEGFITGLL DLLPASYYFR FQREISVALC CALCFVIDLS MVTDGGMYVF QLFDYYSASG 
481:	TTLLWQAFWE CVVVAWVYGA DRFMDDIACM IGYRPCPWMK WCWSFFTPLV CMGIFIFNVV 
541:	YYEPLVYNNT YVYPWWGEAM GWAFALSSML CVPLHLLGCL LRAKGTMAER WQHLTQPIWG 
601:	LHHLEYRAQD ADVRGLTTLT PVSESSKVVV VESVM