2.A.22.3.8
Mouse GABA, β-alanine, fluoro-β-alanine and taurine transporter-3 (GAT3) (Liu et al. 1999). Orthologous to rat and human GAT2; 72% identical to GAT4 (2.A.22.3.7) (takes up GABA with high affinity into presynaptic terminals). Also takes up the carnitine precursor, gamma-butyrobetaine (Nakanishi et al., 2011).
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| Accession Number: | P31649 |
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| Protein Name: | Sodium- and chloride-dependent GABA transporter 2 |
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| Length: | 602 |
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| Molecular Weight: | 68285.00 |
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| Species: | Mus musculus (Mouse) [10090] |
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| Number of TMSs: | 11 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
beta-alanine, taurine, indole-3-butyric acid, 4-(trimethylammonio)butanoate |
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| Entrez Gene ID: |
14412
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| Pfam: |
PF00209
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| KEGG: |
mmu:14412
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[1] “Molecular characterization of four pharmacologically distinct gamma-aminobutyric acid transporters in mouse brain.” Liu Q.-R. et.al. 8420981
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Team et.al. 15489334
[3] “Large-scale phosphorylation analysis of mouse liver.” Villen J. et.al. 17242355
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1: MENRASGTTS NGETKPVCPA MEKVEEDGTL EREHWNNKME FVLSVAGEII GLGNVWRFPY
61: LCYKNGGGAF FIPYLIFLFT CGIPVFFLET ALGQYTNQGG ITAWRRICPI FEGIGYASQM
121: IVSLLNVYYI VVLAWALFYL FSSFTTDLPW GSCSHEWNTE NCVEFQKAND SMNVTSENAT
181: SPVIEFWERR VLKLSDGIQH LGSLRWELVL CLLLAWIICY FCIWKGVKST GKVVYFTATF
241: PYLMLVVLLI RGVTLPGAAQ GIQFYLYPNI TRLWDPQVWM DAGTQIFFSF AICLGCLTAL
301: GSYNKYHNNC YRDCIALCIL NSSTSFMAGF AIFSILGFMS QEQGVPISEV AESGPGLAFI
361: AYPRAVVMLP FSPLWACCFF FMVVLLGLDS QFVCVESLVT ALVDMYPRVF RKKNRREVLI
421: LIVSVISFFI GLIMLTEGGM YVFQLFDYYA ASGMCLLFVA IFESLCVAWV YGAGRFYDNI
481: EDMIGYKPWP LIKYCWLFFT PAVCLATFLF SLIKYTPLTY NKKYTYPWWG DALGWLLALS
541: SMICIPAWSI YKLRTLKGPL RERLRQLVCP AEDLPQKNQP EPTAPATPMT SLLRLTELES
601: NC