Search TCDB: (?)
TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.22.3.9
Sodium- and chloride-dependent GABA transporter 3 (GAT-3) (Solute carrier family 6 member 11). Expression of GAT-3 was selectively decreased within the amygdala of alcohol-choosing rats, and a knockdown of this transcript reversed choice preference of rats that originally chose a sweet solution over alcohol. GAT-3 expression was selectively decreased in the central amygdala of alcohol-dependent people as well. Thus, impaired GABA clearance within the amygdala contributes to alcohol addiction (Augier et al. 2018).

Accession Number:P48066
Protein Name:Sodium- and chloride-dependent GABA transporter 3
Length:632
Molecular Weight:70606.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate chloride, sodium(1+), indole-3-butyric acid

Cross database links:

Entrez Gene ID: 6538   
Pfam: PF00209   
KEGG: hsa:6538   

Gene Ontology

GO:0042995 C:cell projection
GO:0005737 C:cytoplasm
GO:0016021 C:integral to membrane
GO:0005887 C:integral to plasma membrane
GO:0005624 C:membrane fraction
GO:0005886 C:plasma membrane
GO:0005332 F:gamma-aminobutyric acid:sodium symporter activity
GO:0042165 F:neurotransmitter binding
GO:0005328 F:neurotransmitter:sodium symporter activity
GO:0007420 P:brain development
GO:0007269 P:neurotransmitter secretion
GO:0042493 P:response to drug
GO:0055085 P:transmembrane transport

References (2)

[1] “Cloning of the human homologue of the GABA transporter GAT-3 and identification of a novel inhibitor with selectivity for this site.”  Borden L.A.et.al.   7874447
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence 
1:	MTAEKALPLG NGKAAEEARE SEAPGGGCSS GGAAPARHPR VKRDKAVHER GHWNNKVEFV 
61:	LSVAGEIIGL GNVWRFPYLC YKNGGGAFLI PYVVFFICCG IPVFFLETAL GQFTSEGGIT 
121:	CWRKVCPLFE GIGYATQVIE AHLNVYYIII LAWAIFYLSN CFTTELPWAT CGHEWNTENC 
181:	VEFQKLNVSN YSHVSLQNAT SPVMEFWEHR VLAISDGIEH IGNLRWELAL CLLAAWTICY 
241:	FCIWKGTKST GKVVYVTATF PYIMLLILLI RGVTLPGASE GIKFYLYPDL SRLSDPQVWV 
301:	DAGTQIFFSY AICLGCLTAL GSYNNYNNNC YRDCIMLCCL NSGTSFVAGF AIFSVLGFMA 
361:	YEQGVPIAEV AESGPGLAFI AYPKAVTMMP LSPLWATLFF MMLIFLGLDS QFVCVESLVT 
421:	AVVDMYPKVF RRGYRRELLI LALSVISYFL GLVMLTEGGM YIFQLFDSYA ASGMCLLFVA 
481:	IFECICIGWV YGSNRFYDNI EDMIGYRPPS LIKWCWMIMT PGICAGIFIF FLIKYKPLKY 
541:	NNIYTYPAWG YGIGWLMALS SMLCIPLWIC ITVWKTEGTL PEKLQKLTTP STDLKMRGKL 
601:	GVSPRMVTVN DCDAKLKSDG TIAAITEKET HF