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|---|---|
| Accession Number: | Q9NP91 |
| Protein Name: | Sodium- and chloride-dependent transporter XTRP3 |
| Length: | 592 |
| Molecular Weight: | 65914.00 |
| Species: | Homo sapiens (Human) [9606] |
| Number of TMSs: | 12 |
| Location1 / Topology2 / Orientation3: | Apical cell membrane1 / Multi-pass membrane protein2 |
| Substrate | chloride, sodium(1+), alpha-amino acid |
Cross database links:
| Entrez Gene ID: | 54716 |
|---|---|
| Pfam: | PF00209 |
| KEGG: | hsa:54716 |
Gene Ontology
GO:0016324
C:apical plasma membrane
GO:0005887
C:integral to plasma membrane
GO:0015171
F:amino acid transmembrane transporter activity
GO:0005328
F:neurotransmitter:sodium symporter activity
GO:0015816
P:glycine transport
GO:0006811
P:ion transport
GO:0015824
P:proline transport
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References (5)[1] “The LZTFL1 gene is a part of a transcriptional map covering 250 kb within the common eliminated region 1 (C3CER1) in 3p21.3.” Kiss H.et.al. 11352561 [2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [3] “Cloning, gene structure, and genomic localization of an orphan transporter from mouse kidney with six alternatively-spliced isoforms.” Nash S.R.et.al. 9932288 [4] “Identification of mammalian proline transporter SIT1 (SLC6A20) with characteristics of classical system imino.” Takanaga H.et.al. 15632147 [5] “Iminoglycinuria and hyperglycinuria are discrete human phenotypes resulting from complex mutations in proline and glycine transporters.” Broer S.et.al. 19033659
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External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MEKARPLWAN SLQFVFACIS YAVGLGNVWR FPYLCQMYGG GSFLVPYIIM LIVEGMPLLY 61: LELAVGQRMR QGSIGAWRTI SPYLSGVGVA SVVVSFFLSM YYNVINAWAF WYLFHSFQDP 121: LPWSVCPLNG NHTGYDEECE KASSTQYFWY RKTLNISPSL QENGGVQWEP ALCLLLAWLV 181: VYLCILRGTE STGKVVYFTA SLPYCVLIIY LIRGLTLHGA TNGLMYMFTP KIEQLANPKA 241: WINAATQIFF SLGLGFGSLI AFASYNEPSN NCQKHAIIVS LINSFTSIFA SIVTFSIYGF 301: KATFNYENCL KKVSLLLTNT FDLEDGFLTA SNLEQVKGYL ASAYPSKYSE MFPQIKNCSL 361: ESELDTAVQG TGLAFIVYTE AIKNMEVSQL WSVLYFFMLL MLGIGSMLGN TAAILTPLTD 421: SKIISSHLPK EAISGLVCLV NCAIGMVFTM EAGNYWFDIF NDYAATLSLL LIVLVETIAV 481: CYVYGLRRFE SDLKAMTGRA VSWYWKVMWA GVSPLLIVSL FVFYLSDYIL TGTLKYQAWD 541: ASQGQLVTKD YPAYALAVIG LLVASSTMCI PLAALGTFVQ RRLKRGDADP VA