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2.A.23.1.1 Glutamate/aspartate:H⁺ symporter, GltP or GltT; has 8 TMSs with 2 re-entrant loops as for GltPh (TC# 2.A.23.1.5). GltP residues involved in substrate binding and transport have been identified, especially in transmembrane helices VII and VIII (Rahman et al. 2016).
Accession Number:	P21345
Protein Name:	GltP aka B4077
Length:	437
Molecular Weight:	47159.00
Species:	Escherichia coli [83333]
Number of TMSs:	10
Location¹ / Topology² / Orientation³:	Cell inner membrane¹ / Multi-pass membrane protein²
Substrate	glutamate(2-), aspartate(2-)

RefSeq:	AP_004578.1 NP_418501.1
Entrez Gene ID:	948591
Pfam:	PF00375
BioCyc:	EcoCyc:GLTP-MONOMER ECOL168927:B4077-MONOMER
KEGG:	ecj:JW4038 eco:b4077
Gene Ontology GO:0016021 C:integral to membrane GO:0005886 C:plasma membrane GO:0017153 F:sodium:dicarboxylate symporter activity GO:0006835 P:dicarboxylic acid transport
References (6) [1] “Cloning and sequencing of a gene encoding a glutamate and aspartate carrier of Escherichia coli K-12.” Wallace B.et.al. 1971622 [2] “Revised nucleotide sequence of the gltP gene, which encodes the proton-glutamate-aspartate transport protein of Escherichia coli K-12.” Tolner B.et.al. 1551855 [3] “Analysis of the Escherichia coli genome. IV. DNA sequence of the region from 89.2 to 92.8 minutes.” Blattner F.R.et.al. 8265357 [4] “The complete genome sequence of Escherichia coli K-12.” Blattner F.R.et.al. 9278503 [5] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.” Hayashi K.et.al. 16738553 [6] “Global topology analysis of the Escherichia coli inner membrane proteome.” Daley D.O.et.al. 15919996

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

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FASTA formatted sequence

1:	MKNIKFSLAW QILFAMVLGI LLGSYLHYHS DSRDWLVVNL LSPAGDIFIH LIKMIVVPIV 
61:	ISTLVVGIAG VGDAKQLGRI GAKTIIYFEV ITTVAIILGI TLANVFQPGA GVDMSQLATV 
121:	DISKYQSTTE AVQSSSHGIM GTILSLVPTN IVASMAKGEM LPIIFFSVLF GLGLSSLPAT 
181:	HREPLVTVFR SISETMFKVT HMVMRYAPVG VFALIAVTVA NFGFSSLWPL AKLVLLVHFA 
241:	ILFFALVVLG IVARLCGLSV WILIRILKDE LILAYSTASS ESVLPRIIEK MEAYGAPVSI 
301:	TSFVVPTGYS FNLDGSTLYQ SIAAIFIAQL YGIDLSIWQE IILVLTLMVT SKGIAGVPGV 
361:	SFVVLLATLG SVGIPLEGLA FIAGVDRILD MARTALNVVG NALAVLVIAK WEHKFDRKKA 
421:	LAYEREVLGK FDKTADQ

2.A.23.1.1
Glutamate/aspartate:H⁺ symporter, GltP or GltT; has 8 TMSs with 2 re-entrant loops as for GltPh (TC# 2.A.23.1.5). GltP residues involved in substrate binding and transport have been identified, especially in transmembrane helices VII and VIII (Rahman et al. 2016).

Cross database links:

Gene Ontology

References (6)

External Searches:

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2.A.23.1.1Glutamate/aspartate:H+ symporter, GltP or GltT; has 8 TMSs with 2 re-entrant loops as for GltPh (TC# 2.A.23.1.5). GltP residues involved in substrate binding and transport have been identified, especially in transmembrane helices VII and VIII (Rahman et al. 2016).

Cross database links:

Gene Ontology

References (6)

External Searches:

Analyze:

2.A.23.1.1
Glutamate/aspartate:H⁺ symporter, GltP or GltT; has 8 TMSs with 2 re-entrant loops as for GltPh (TC# 2.A.23.1.5). GltP residues involved in substrate binding and transport have been identified, especially in transmembrane helices VII and VIII (Rahman et al. 2016).