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Accession Number: | P43005 |
Protein Name: | EAA3 aka SLC1A1 aka EAAT3 aka EAAC1 |
Length: | 524 |
Molecular Weight: | 57100.00 |
Species: | Homo sapiens (Human) [9606] |
Number of TMSs: | 9 |
Location1 / Topology2 / Orientation3: | Membrane1 / Multi-pass membrane protein2 |
Substrate | lithium(1+), sodium(1+), potassium(1+), cysteine, glutamate(2-), aspartate(2-) |
Cross database links:
RefSeq: | NP_004161.4 |
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Entrez Gene ID: | 6505 |
Pfam: | PF00375 |
OMIM: |
133550 gene 222730 phenotype |
KEGG: | hsa:6505 hsa:6505 |
Gene Ontology
GO:0005887
C:integral to plasma membrane
GO:0005624
C:membrane fraction
GO:0017153
F:sodium:dicarboxylate symporter activity
GO:0070779
P:D-aspartate import
GO:0006835
P:dicarboxylic acid transport
GO:0051938
P:L-glutamate import
GO:0007268
P:synaptic transmission
GO:0016595
F:glutamate binding
GO:0015501
F:glutamate:sodium symporter activity
GO:0005313
F:L-glutamate transmembrane transporter activity
GO:0051260
P:protein homooligomerization
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References (12)[1] “Neuron-specific human glutamate transporter: molecular cloning, characterization and expression in human brain.” Shashidharan P.et.al. 7859077 [2] “The neuronal and epithelial human high affinity glutamate transporter. Insights into structure and mechanism of transport.” Kanai Y.et.al. 7914198 [3] “Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex.” Arriza J.L.et.al. 7521911 [4] “Genomic organization of the SLC1A1/EAAC1 gene and mutation screening in early-onset obsessive-compulsive disorder.” Veenstra-VanderWeele J.et.al. 11317217 [5] “DNA sequence and analysis of human chromosome 9.” Humphray S.J.et.al. 15164053 [6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [7] “Neuron-specific human glutamate transporter: molecular cloning, characterization and expression in human brain.” Shashidharan P.et.al. 7859077 [8] “The neuronal and epithelial human high affinity glutamate transporter. Insights into structure and mechanism of transport.” Kanai Y.et.al. 7914198 | |
Structure: | |
External Searches:
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Analyze:
Predict TMSs (Predict number of transmembrane segments) | ||||
FASTA formatted sequence |
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1: MGKPARKGCE WKRFLKNNWV LLSTVAAVVL GITTGVLVRE HSNLSTLEKF YFAFPGEILM 61: RMLKLIILPL IISSMITGVA ALDSNVSGKI GLRAVVYYFC TTLIAVILGI VLVVSIKPGV 121: TQKVGEIART GSTPEVSTVD AMLDLIRNMF PENLVQACFQ QYKTKREEVK PPSDPEMNMT 181: EESFTAVMTT AISKNKTKEY KIVGMYSDGI NVLGLIVFCL VFGLVIGKMG EKGQILVDFF 241: NALSDATMKI VQIIMCYMPL GILFLIAGKI IEVEDWEIFR KLGLYMATVL TGLAIHSIVI 301: LPLIYFIVVR KNPFRFAMGM AQALLTALMI SSSSATLPVT FRCAEENNQV DKRITRFVLP 361: VGATINMDGT ALYEAVAAVF IAQLNDLDLG IGQIITISIT ATSASIGAAG VPQAGLVTMV 421: IVLSAVGLPA EDVTLIIAVD WLLDRFRTMV NVLGDAFGTG IVEKLSKKEL EQMDVSSEVN 481: IVNPFALEST ILDNEDSDTK KSYVNGGFAV DKSDTISFTQ TSQF