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Accession Number: | P43003 |
Protein Name: | Excitatory amino acid transporter 1 |
Length: | 542 |
Molecular Weight: | 59572.00 |
Species: | Homo sapiens (Human) [9606] |
Number of TMSs: | 10 |
Location1 / Topology2 / Orientation3: | Membrane1 / Multi-pass membrane protein2 |
Substrate | sodium(1+), glutamate(2-), aspartate(2-) |
Cross database links:
Entrez Gene ID: | 6507 |
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Pfam: | PF00375 |
KEGG: | hsa:6507 |
Gene Ontology
GO:0016323
C:basolateral plasma membrane
GO:0009986
C:cell surface
GO:0043197
C:dendritic spine
GO:0043205
C:fibril
GO:0016021
C:integral to membrane
GO:0005624
C:membrane fraction
GO:0005743
C:mitochondrial inner membrane
GO:0043025
C:neuronal cell body
GO:0005886
C:plasma membrane
GO:0045202
C:synapse
GO:0016595
F:glutamate binding
GO:0005314
F:high-affinity glutamate transmembrane transporter activity
GO:0005313
F:L-glutamate transmembrane transporter activity
GO:0017153
F:sodium:dicarboxylate symporter activity
GO:0031223
P:auditory behavior
GO:0048667
P:cell morphogenesis involved in neuron differentiation
GO:0021545
P:cranial nerve development
GO:0070779
P:D-aspartate import
GO:0009449
P:gamma-aminobutyric acid biosynthetic process
GO:0006537
P:glutamate biosynthetic process
GO:0051938
P:L-glutamate import
GO:0043490
P:malate-aspartate shuttle
GO:0050885
P:neuromuscular process controlling balance
GO:0001504
P:neurotransmitter uptake
GO:0050806
P:positive regulation of synaptic transmission
GO:0046677
P:response to antibiotic
GO:0042493
P:response to drug
GO:0010035
P:response to inorganic substance
GO:0009416
P:response to light stimulus
GO:0009611
P:response to wounding
GO:0007605
P:sensory perception of sound
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References (9)[1] “Cloning and characterization of a glutamate transporter cDNA from human cerebellum.” Shashidharan P.et.al. 8218410 [2] “Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex.” Arriza J.L.et.al. 7521911 [3] “Cloning and expression of a human glutamate transporter.” Kawakami H.et.al. 8123008 [4] “Human high affinity, Na(+)-dependent L-glutamate/L-aspartate transporter GLAST-1 (EAAT-1): gene structure and localization to chromosome 5p11-p12.” Stoffel W.et.al. 8647279 [5] “A novel alternative splicing form of excitatory amino acid transporter 1 is a negative regulator of glutamate uptake.” Vallejo-Illarramendi A.et.al. 16042756 | |
Structure: | |
External Searches:
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Analyze:
Predict TMSs (Predict number of transmembrane segments) | ||||
FASTA formatted sequence |
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1: MTKSNGEEPK MGGRMERFQQ GVRKRTLLAK KKVQNITKED VKSYLFRNAF VLLTVTAVIV 61: GTILGFTLRP YRMSYREVKY FSFPGELLMR MLQMLVLPLI ISSLVTGMAA LDSKASGKMG 121: MRAVVYYMTT TIIAVVIGII IVIIIHPGKG TKENMHREGK IVRVTAADAF LDLIRNMFPP 181: NLVEACFKQF KTNYEKRSFK VPIQANETLV GAVINNVSEA METLTRITEE LVPVPGSVNG 241: VNALGLVVFS MCFGFVIGNM KEQGQALREF FDSLNEAIMR LVAVIMWYAP VGILFLIAGK 301: IVEMEDMGVI GGQLAMYTVT VIVGLLIHAV IVLPLLYFLV TRKNPWVFIG GLLQALITAL 361: GTSSSSATLP ITFKCLEENN GVDKRVTRFV LPVGATINMD GTALYEALAA IFIAQVNNFE 421: LNFGQIITIS ITATAASIGA AGIPQAGLVT MVIVLTSVGL PTDDITLIIA VDWFLDRLRT 481: TTNVLGDSLG AGIVEHLSRH ELKNRDVEMG NSVIEENEMK KPYQLIAQDN ETEKPIDSET 541: KM