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Accession Number: | P43004 |
Protein Name: | Excitatory amino acid transporter 2 |
Length: | 574 |
Molecular Weight: | 62104.00 |
Species: | Homo sapiens (Human) [9606] |
Number of TMSs: | 9 |
Location1 / Topology2 / Orientation3: | Membrane1 / Multi-pass membrane protein2 |
Substrate | sodium(1+), glutamate(2-), aspartate(2-) |
Cross database links:
Entrez Gene ID: | 6506 |
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Pfam: | PF00375 |
KEGG: | hsa:6506 |
Gene Ontology
GO:0030673
C:axolemma
GO:0043198
C:dendritic shaft
GO:0043197
C:dendritic spine
GO:0016021
C:integral to membrane
GO:0005624
C:membrane fraction
GO:0005886
C:plasma membrane
GO:0042734
C:presynaptic membrane
GO:0015501
F:glutamate:sodium symporter activity
GO:0005314
F:high-affinity glutamate transmembrane transporter activity
GO:0005313
F:L-glutamate transmembrane transporter activity
GO:0017153
F:sodium:dicarboxylate symporter activity
GO:0030534
P:adult behavior
GO:0031668
P:cellular response to extracellular stimulus
GO:0070779
P:D-aspartate import
GO:0051938
P:L-glutamate import
GO:0035264
P:multicellular organism growth
GO:0010259
P:multicellular organismal aging
GO:0046326
P:positive regulation of glucose import
GO:0043200
P:response to amino acid stimulus
GO:0042493
P:response to drug
GO:0009611
P:response to wounding
GO:0007268
P:synaptic transmission
GO:0021537
P:telencephalon development
GO:0007632
P:visual behavior
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References (9)[1] “Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex.” Arriza J.L.et.al. 7521911 [2] “Molecular cloning of human brain glutamate/aspartate transporter II.” Shashidharan P.et.al. 8172925 [3] “Cloning and characterization of a glutamate transporter cDNA from human brain and pancreas.” Manfras B.J.et.al. 7522567 [4] “DL-threo-beta-benzyloxyaspartate, a potent blocker of excitatory amino acid transporters.” Shimamoto K.et.al. 9463476 [5] “Cloning and characterization of the 3'-untranslated region of the human excitatory amino acid transporter 2 transcript.” Kim S.Y.et.al. 12950454 |
External Searches:
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Analyze:
Predict TMSs (Predict number of transmembrane segments) | ||||
FASTA formatted sequence |
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1: MASTEGANNM PKQVEVRMHD SHLGSEEPKH RHLGLRLCDK LGKNLLLTLT VFGVILGAVC 61: GGLLRLASPI HPDVVMLIAF PGDILMRMLK MLILPLIISS LITGLSGLDA KASGRLGTRA 121: MVYYMSTTII AAVLGVILVL AIHPGNPKLK KQLGPGKKND EVSSLDAFLD LIRNLFPENL 181: VQACFQQIQT VTKKVLVAPP PDEEANATSA VVSLLNETVT EVPEETKMVI KKGLEFKDGM 241: NVLGLIGFFI AFGIAMGKMG DQAKLMVDFF NILNEIVMKL VIMIMWYSPL GIACLICGKI 301: IAIKDLEVVA RQLGMYMVTV IIGLIIHGGI FLPLIYFVVT RKNPFSFFAG IFQAWITALG 361: TASSAGTLPV TFRCLEENLG IDKRVTRFVL PVGATINMDG TALYEAVAAI FIAQMNGVVL 421: DGGQIVTVSL TATLASVGAA SIPSAGLVTM LLILTAVGLP TEDISLLVAV DWLLDRMRTS 481: VNVVGDSFGA GIVYHLSKSE LDTIDSQHRV HEDIEMTKTQ SIYDDMKNHR ESNSNQCVYA 541: AHNSVIVDEC KVTLAANGKS ADCSVEEEPW KREK