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2.A.25 The Alanine or Glycine:Cation Symporter (AGCS) Family

Members of the AGCS family transport alanine and/or glycine in symport with Na+ and or H+. The proteins are of 445-542 amino acyl residues in length and possess 8-12 putative transmembrane α-helical spanners. They may possess 11 TMSs as seems to be true for DagA and AgcS, although Acp has only 8 (truncated?). They are found in bacteria and archaea. Only three members of the family have been functionally characterized. These proteins show limited sequence similarity in the APC family (TC# 2.A.3), and homology has been established.

The generalized transport reaction catalyzed by the AGCS family is:

alanine or glycine (out) + Na+ or H+ (out) → alanine or glycine (in) + Na+ or H+ (in).

This family belongs to the: APC Superfamily.

References associated with 2.A.25 family:

Bualuang A., Kageyama H., Tanaka Y., Incharoensakdi A. and Takabe T. (201). Functional characterization of a member of alanine or glycine: cation symporter family in halotolerant cyanobacterium Aphanothece halophytica. Biosci Biotechnol Biochem. 79(2):230-5. 25421789
Kamata, H., S. Akiyama, H. Morosawa, T. Ohta, T. Hamamoto, T. Kambe, Y. Kagawa, and H. Hirata. (1992). Primary structure of the alanine carrier protein of thermophilic bacterium PS3. J. Biol. Chem. 267: 21650-21655. 1400476
Kanamori, M., H. Kamata, H. Yagisawa, and H. Hirata. (1999). Overexpression of the alanine carrier protein gene from thermophilic bacterium PS3 in Escherichia coli. J Biochem 125: 454-459. 10050032
Moore, B.C. and J.A. Leigh. (2005). Markerless mutagenesis in Methanococcus maripaludis demonstrates roles for alanine dehydrogenase, alanine racemase, and alanine permease. J. Bacteriol. 187: 972-979. 15659675
Reizer, J., A. Reizer and M.H. Saier, Jr. (1994). A functional superfamily of sodium/solute symporters. Biochim. Biophys. Acta 1197: 133-166. 8031825
Rodionov, D.A., P. Hebbeln, A. Eudes, J. ter Beek, I.A. Rodionova, G.B. Erkens, D.J. Slotboom, M.S. Gelfand, A.L. Osterman, A.D. Hanson, and T. Eitinger. (2009). A novel class of modular transporters for vitamins in prokaryotes. J. Bacteriol. 191: 42-51. 18931129
Rodionov, D.A., P.S. Novichkov, E.D. Stavrovskaya, I.A. Rodionova, X. Li, M.D. Kazanov, D.A. Ravcheev, A.V. Gerasimova, A.E. Kazakov, G.Y. Kovaleva, E.A. Permina, O.N. Laikova, R. Overbeek, M.F. Romine, J.K. Fredrickson, A.P. Arkin, I. Dubchak, A.L. Osterman, and M.S. Gelfand. (2011). Comparative genomic reconstruction of transcriptional networks controlling central metabolism in the Shewanella genus. BMC Genomics 12Suppl1: S3. 21810205
Yoshida, K., H. Yamaguchi, M. Kinehara, Y.H. Ohki, Y. Nakaura, and Y. Fujita. (2003). Identification of additional TnrA-regulated genes of Bacillus subtilis associated with a TnrA box. Mol. Microbiol. 49: 157-165. 12823818