TCDB » SEARCH

« See all members of the family

2.A.27.1.1 Glutamate:Na⁺ symporter, GltS, of 401 aas and 12 TMSs. It transports L- and D-glutamate, α-methylglutamate and homocysteate. Swapping the order of the two halves (repeat units) does not decrease activity (Dobrowolski and Lolkema, 2010).
Accession Number:	P0AER8
Protein Name:	Sodium/glutamate symport carrier protein GltS aka GLTC aka B3653
Length:	401
Molecular Weight:	42425.00
Species:	Escherichia coli [83333]
Number of TMSs:	10
Location¹ / Topology² / Orientation³:	Cell inner membrane¹ / Multi-pass membrane protein²
Substrate	L-glutamate(1-), glutamate(2-)

DIP:	DIP-48023N
RefSeq:	AP_004139.1 NP_418110.1
Entrez Gene ID:	948166
Pfam:	PF03616
BioCyc:	EcoCyc:GLTS-MONOMER ECOL168927:B3653-MONOMER
KEGG:	ecj:JW3628 eco:b3653
Gene Ontology GO:0016021 C:integral to membrane GO:0005886 C:plasma membrane GO:0015501 F:glutamate:sodium symporter activity GO:0015813 P:L-glutamate transport GO:0006814 P:sodium ion transport
References (7) [1] “Nucleotide sequence of gltS, the Na+/glutamate symport carrier gene of Escherichia coli B.” Deguchi Y.et.al. 2254324 [2] “Characterization of the Escherichia coli K12 gltS glutamate permease gene.” Kalman M.et.al. 2017136 [3] “DNA sequence and analysis of 136 kilobases of the Escherichia coli genome: organizational symmetry around the origin of replication.” Burland V.D.et.al. 7686882 [4] “The complete genome sequence of Escherichia coli K-12.” Blattner F.R.et.al. 9278503 [5] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.” Hayashi K.et.al. 16738553 [6] “The nucleotide sequence of recG, the distal spo operon gene in Escherichia coli K-12.” Kalman M.et.al. 1544582 [7] “Global topology analysis of the Escherichia coli inner membrane proteome.” Daley D.O.et.al. 15919996

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MFHLDTLATL VAATLTLLLG RKLVHSVSFL KKYTIPEPVA GGLLVALALL VLKKSMGWEV 
61:	NFDMSLRDPL MLAFFATIGL NANIASLRAG GRVVGIFLIV VVGLLVMQNA IGIGMASLLG 
121:	LDPLMGLLAG SITLSGGHGT GAAWSKLFIE RYGFTNATEV AMACATFGLV LGGLIGGPVA 
181:	RYLVKHSTTP NGIPDDQEVP TAFEKPDVGR MITSLVLIET IALIAICLTV GKIVAQLLAG 
241:	TAFELPTFVC VLFVGVILSN GLSIMGFYRV FERAVSVLGN VSLSLFLAMA LMGLKLWELA 
301:	SLALPMLAIL VVQTIFMALY AIFVTWRMMG KNYDAAVLAA GHCGFGLGAT PTAIANMQAI 
361:	TERFGPSHMA FLVVPMVGAF FIDIVNALVI KLYLMLPIFA G

2.A.27.1.1
Glutamate:Na⁺ symporter, GltS, of 401 aas and 12 TMSs. It transports L- and D-glutamate, α-methylglutamate and homocysteate. Swapping the order of the two halves (repeat units) does not decrease activity (Dobrowolski and Lolkema, 2010).

Cross database links:

Gene Ontology

References (7)

External Searches:

Analyze:

2.A.27.1.1Glutamate:Na+ symporter, GltS, of 401 aas and 12 TMSs. It transports L- and D-glutamate, α-methylglutamate and homocysteate. Swapping the order of the two halves (repeat units) does not decrease activity (Dobrowolski and Lolkema, 2010).

Cross database links:

Gene Ontology

References (7)

External Searches:

Analyze:

2.A.27.1.1
Glutamate:Na⁺ symporter, GltS, of 401 aas and 12 TMSs. It transports L- and D-glutamate, α-methylglutamate and homocysteate. Swapping the order of the two halves (repeat units) does not decrease activity (Dobrowolski and Lolkema, 2010).