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Accession Number: | Q12908 |
Protein Name: | Ileal sodium/bile acid cotransporter |
Length: | 348 |
Molecular Weight: | 37698.00 |
Species: | Homo sapiens (Human) [9606] |
Number of TMSs: | 9 |
Location1 / Topology2 / Orientation3: | Membrane1 / Multi-pass membrane protein2 |
Substrate | bile acid conjugate, bile acid |
Cross database links:
RefSeq: | NP_000443.1 |
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Entrez Gene ID: | 6555 |
Pfam: | PF01758 |
OMIM: |
601295 gene+phenotype |
KEGG: | hsa:6555 hsa:6555 |
Gene Ontology
GO:0005887
C:integral to plasma membrane
GO:0008508
F:bile acid:sodium symporter activity
GO:0015711
P:organic anion transport
GO:0006814
P:sodium ion transport
GO:0016324
C:apical plasma membrane
GO:0005634
C:nucleus
GO:0000502
C:proteasome complex
GO:0008206
P:bile acid metabolic process
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References (16)[1] “Identification of a mutation in the ileal sodium-dependent bile acid transporter gene that abolishes transport activity.” Wong M.H.et.al. 7592981 [2] “Primary bile acid malabsorption caused by mutations in the ileal sodium-dependent bile acid transporter gene (SLC10A2).” Oelkers P.et.al. 9109432 [3] “Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia.” Chumakov I.et.al. 12364586 [4] “The DNA sequence and analysis of human chromosome 13.” Dunham A.et.al. 15057823 [5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [6] “Topology scanning and putative three-dimensional structure of the extracellular binding domains of the apical sodium-dependent bile acid transporter (SLC10A2).” Zhang E.Y.et.al. 15350125 [7] “Analysis of the ileal bile acid transporter gene, SLC10A2, in subjects with familial hypertriglyceridemia.” Love M.W.et.al. 11742882 [8] “Absence of dysfunctional ileal sodium-bile acid cotransporter gene mutations in patients with adult-onset idiopathic bile acid malabsorption.” Montagnani M.et.al. 11589382 [9] “Identification of a mutation in the ileal sodium-dependent bile acid transporter gene that abolishes transport activity.” Wong M.H.et.al. 7592981 [10] “Primary bile acid malabsorption caused by mutations in the ileal sodium-dependent bile acid transporter gene (SLC10A2).” Oelkers P.et.al. 9109432 [11] “Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia.” Chumakov I.et.al. 12364586 [12] “The DNA sequence and analysis of human chromosome 13.” Dunham A.et.al. 15057823 [13] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [14] “Topology scanning and putative three-dimensional structure of the extracellular binding domains of the apical sodium-dependent bile acid transporter (SLC10A2).” Zhang E.Y.et.al. 15350125 [15] “Analysis of the ileal bile acid transporter gene, SLC10A2, in subjects with familial hypertriglyceridemia.” Love M.W.et.al. 11742882 [16] “Absence of dysfunctional ileal sodium-bile acid cotransporter gene mutations in patients with adult-onset idiopathic bile acid malabsorption.” Montagnani M.et.al. 11589382
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External Searches:
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Analyze:
Predict TMSs (Predict number of transmembrane segments) | ||||
FASTA formatted sequence |
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1: MNDPNSCVDN ATVCSGASCV VPESNFNNIL SVVLSTVLTI LLALVMFSMG CNVEIKKFLG 61: HIKRPWGICV GFLCQFGIMP LTGFILSVAF DILPLQAVVV LIIGCCPGGT ASNILAYWVD 121: GDMDLSVSMT TCSTLLALGM MPLCLLIYTK MWVDSGSIVI PYDNIGTSLV ALVVPVSIGM 181: FVNHKWPQKA KIILKIGSIA GAILIVLIAV VGGILYQSAW IIAPKLWIIG TIFPVAGYSL 241: GFLLARIAGL PWYRCRTVAF ETGMQNTQLC STIVQLSFTP EELNVVFTFP LIYSIFQLAF 301: AAIFLGFYVA YKKCHGKNKA EIPESKENGT EPESSFYKAN GGFQPDEK