2.A.28.3.1
Solute carrier family 10, member 7 protein (358 aas. Present in the plasma membrane with 10 established TMSs with the N- and C-termini in the cytoplasm (Godoy et al. 2007)) (Zou et al., 2005).  Slc10a7 KO mice exhibit moderate skeletal dysplasia (osteochondrodyplasia), characterized by markedly shortened and mildly bowed limbs (Brommage et al. 2014). SLC10A7 plays roles in glycosaminoglycan synthesis and skeletal development, and mutants in its gene can cause skeletal dysplasia in mice and humans (Dubail et al. 2018). It plays a role in bone mineralization and transport of glycoproteins to the extracellular matrix (Ashikov et al. 2018). However it has been reported to not show transport activity towards bile acids and steroid sulfates (including taurocholate, cholate, chenodeoxycholate, estrone-3-sulfate, dehydroepiandrosterone sulfate (DHEAS) and pregnenolone sulfate) (Godoy et al. 2007). SLC10A7 regulates O-GalNAc glycosylation and Ca²⁺ homeostasis in the secretory pathway (Durin et al. 2025).