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2.A.29.14.6 solute carrier family 25, member 40. This mitochondrial inner membrane transporter can be mutated (Y125C) to give hypertriglyceridemia (Rosenthal et al. 2013). May also be involved in primary Sjögren's syndrome (pSS), a prevalent and disabling form of fatigue (Norheim et al. 2014).
Accession Number:	Q8TBP6
Protein Name:	Solute carrier family 25 member 40
Length:	338
Molecular Weight:	38125.00
Species:	Homo sapiens (Human) [9606]
Number of TMSs:	6
Location¹ / Topology² / Orientation³:	Mitochondrion inner membrane¹ / Multi-pass membrane protein²
Substrate

Entrez Gene ID:	55972
Pfam:	PF00153
KEGG:	hsa:55972 hsa:55972
Gene Ontology GO:0016021 C:integral to membrane GO:0005743 C:mitochondrial inner membrane GO:0005488 F:binding GO:0055085 P:transmembrane transport
References (10) [1] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [2] “The DNA sequence of human chromosome 7.” Hillier L.W.et.al. 12853948 [3] “Human chromosome 7: DNA sequence and biology.” Scherer S.W.et.al. 12690205 [4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [5] “Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system.” Haitina T.et.al. 16949250 [6] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [7] “The DNA sequence of human chromosome 7.” Hillier L.W.et.al. 12853948 [8] “Human chromosome 7: DNA sequence and biology.” Scherer S.W.et.al. 12690205 [9] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [10] “Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system.” Haitina T.et.al. 16949250

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MDPETRGQEI IKVTPLQQML ASCTGAILTS VIVTPLDVVK IRLQAQNNPL PKGKCFVYSN 
61:	GLMDHLCVCE EGGNKLWYKK PGNFQGTLDA FFKIIRNEGI KSLWSGLPPT LVMAVPATVI 
121:	YFTCYDQLSA LLRSKLGENE TCIPIVAGIV ARFGAVTVIS PLELIRTKMQ SKKFSYVELH 
181:	RFVSKKVSED GWISLWRGWA PTVLRDVPFS AMYWYNYEIL KKWLCEKSGL YEPTFMINFT 
241:	SGALSGSFAA VATLPFDVVK TQKQTQLWTY ESHKISMPLH MSTWIIMKNI VAKNGFSGLF 
301:	SGLIPRLIKI APACAIMIST YEFGKAFFQK QNVRRQQY

2.A.29.14.6
solute carrier family 25, member 40. This mitochondrial inner membrane transporter can be mutated (Y125C) to give hypertriglyceridemia (Rosenthal et al. 2013). May also be involved in primary Sjögren's syndrome (pSS), a prevalent and disabling form of fatigue (Norheim et al. 2014).

Cross database links:

Gene Ontology

References (10)

External Searches:

Analyze:

2.A.29.14.6solute carrier family 25, member 40. This mitochondrial inner membrane transporter can be mutated (Y125C) to give hypertriglyceridemia (Rosenthal et al. 2013). May also be involved in primary Sjögren's syndrome (pSS), a prevalent and disabling form of fatigue (Norheim et al. 2014).

Cross database links:

Gene Ontology

References (10)

External Searches:

Analyze:

2.A.29.14.6
solute carrier family 25, member 40. This mitochondrial inner membrane transporter can be mutated (Y125C) to give hypertriglyceridemia (Rosenthal et al. 2013). May also be involved in primary Sjögren's syndrome (pSS), a prevalent and disabling form of fatigue (Norheim et al. 2014).