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2.A.29.5.2 MRS4 iron (Fe²⁺) import carrier in the inner mitochondrial membrane; essential for erythroid iron utilization) (Mühlenhoff et al., 2003). Uptake is dependent on the pH gradient (Froschauer et al. 2009).
Accession Number:	P23500
Protein Name:	MRS4 aka YKR052C
Length:	304
Molecular Weight:	33307.00
Species:	Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:	6
Location¹ / Topology² / Orientation³:	Mitochondrion inner membrane¹ / Multi-pass membrane protein²
Substrate	iron(2+)

DIP:	DIP-4751N
RefSeq:	NP_012978.1
Entrez Gene ID:	853926
Pfam:	PF00153
KEGG:	sce:YKR052C
Gene Ontology GO:0016021 C:integral to membrane GO:0005743 C:mitochondrial inner membrane GO:0005488 F:binding GO:0005381 F:iron ion transmembrane transporter activity GO:0048250 P:mitochondrial iron ion transport GO:0006397 P:mRNA processing GO:0008380 P:RNA splicing GO:0055085 P:transmembrane transport
References (3) [1] “MRS3 and MRS4, two suppressors of mtRNA splicing defects in yeast, are new members of the mitochondrial carrier family.” Wiesenberger G.et.al. 1703236 [2] “Complete DNA sequence of yeast chromosome XI.” Dujon B.et.al. 8196765 [3] “Global analysis of protein expression in yeast.” Ghaemmaghami S.et.al. 14562106

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FASTA formatted sequence

1:	MNTSELSIAE EIDYEALPSH APLHSQLLAG AFAGIMEHSL MFPIDALKTR VQAAGLNKAA 
61:	STGMISQISK ISTMEGSMAL WKGVQSVILG AGPAHAVYFG TYEFCKARLI SPEDMQTHQP 
121:	MKTALSGTIA TIAADALMNP FDTVKQRLQL DTNLRVWNVT KQIYQNEGFA AFYYSYPTTL 
181:	AMNIPFAAFN FMIYESASKF FNPQNSYNPL IHCLCGGISG ATCAALTTPL DCIKTVLQVR 
241:	GSETVSIEIM KDANTFGRAS RAILEVHGWK GFWRGLKPRI VANIPATAIS WTAYECAKHF 
301:	LMKN

2.A.29.5.2
MRS4 iron (Fe²⁺) import carrier in the inner mitochondrial membrane; essential for erythroid iron utilization) (Mühlenhoff et al., 2003). Uptake is dependent on the pH gradient (Froschauer et al. 2009).

Cross database links:

Gene Ontology

References (3)

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2.A.29.5.2MRS4 iron (Fe2+) import carrier in the inner mitochondrial membrane; essential for erythroid iron utilization) (Mühlenhoff et al., 2003). Uptake is dependent on the pH gradient (Froschauer et al. 2009).

Cross database links:

Gene Ontology

References (3)

External Searches:

Analyze:

2.A.29.5.2
MRS4 iron (Fe²⁺) import carrier in the inner mitochondrial membrane; essential for erythroid iron utilization) (Mühlenhoff et al., 2003). Uptake is dependent on the pH gradient (Froschauer et al. 2009).