TCDB » SEARCH

« See all members of the family

2.A.3.1.1 Phenylalanine:H⁺ symporter, PheP of 458 aas and 12 established TMSs (Pi and Pittard 1996; Pi et al. 2002). Catalytic residues have been identified (Pi et al. 1993), and interhelical interactions have been proposed (Dogovski et al. 2003).
Accession Number:	P24207
Protein Name:	PheP aka B0576
Length:	458
Molecular Weight:	50677.00
Species:	Escherichia coli [83333]
Number of TMSs:	12
Location¹ / Topology² / Orientation³:	Cell inner membrane¹ / Multi-pass membrane protein²
Substrate	phenylalanine

DIP:	DIP-10479N
RefSeq:	AP_001221.1 NP_415108.1
Entrez Gene ID:	945199
Pfam:	PF00324
BioCyc:	EcoCyc:PHEP-MONOMER ECOL168927:B0576-MONOMER
KEGG:	ecj:JW0565 eco:b0576
Gene Ontology GO:0016021 C:integral to membrane GO:0005886 C:plasma membrane GO:0015171 F:amino acid transmembrane transporter activity GO:0006865 P:amino acid transport GO:0055085 P:transmembrane transport
References (6) [1] “Cloning and sequencing of the pheP gene, which encodes the phenylalanine-specific transport system of Escherichia coli.” Pi J.et.al. 1711024 [2] “A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map.” Oshima T.et.al. 8905232 [3] “The complete genome sequence of Escherichia coli K-12.” Blattner F.R.et.al. 9278503 [4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.” Hayashi K.et.al. 16738553 [5] “Topology of the phenylalanine-specific permease of Escherichia coli.” Pi J.et.al. 8626334 [6] “Global topology analysis of the Escherichia coli inner membrane proteome.” Daley D.O.et.al. 15919996

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MKNASTVSED TASNQEPTLH RGLHNRHIQL IALGGAIGTG LFLGIGPAIQ MAGPAVLLGY 
61:	GVAGIIAFLI MRQLGEMVVE EPVSGSFAHF AYKYWGPFAG FLSGWNYWVM FVLVGMAELT 
121:	AAGIYMQYWF PDVPTWIWAA AFFIIINAVN LVNVRLYGET EFWFALIKVL AIIGMIGFGL 
181:	WLLFSGHGGE KASIDNLWRY GGFFATGWNG LILSLAVIMF SFGGLELIGI TAAEARDPEK 
241:	SIPKAVNQVV YRILLFYIGS LVVLLALYPW VEVKSNSSPF VMIFHNLDSN VVASALNFVI 
301:	LVASLSVYNS GVYSNSRMLF GLSVQGNAPK FLTRVSRRGV PINSLMLSGA ITSLVVLINY 
361:	LLPQKAFGLL MALVVATLLL NWIMICLAHL RFRAAMRRQG RETQFKALLY PFGNYLCIAF 
421:	LGMILLLMCT MDDMRLSAIL LPVWIVFLFM AFKTLRRK

2.A.3.1.1
Phenylalanine:H⁺ symporter, PheP of 458 aas and 12 established TMSs (Pi and Pittard 1996; Pi et al. 2002). Catalytic residues have been identified (Pi et al. 1993), and interhelical interactions have been proposed (Dogovski et al. 2003).

Cross database links:

Gene Ontology

References (6)

External Searches:

Analyze:

2.A.3.1.1Phenylalanine:H+ symporter, PheP of 458 aas and 12 established TMSs (Pi and Pittard 1996; Pi et al. 2002). Catalytic residues have been identified (Pi et al. 1993), and interhelical interactions have been proposed (Dogovski et al. 2003).

Cross database links:

Gene Ontology

References (6)

External Searches:

Analyze:

2.A.3.1.1
Phenylalanine:H⁺ symporter, PheP of 458 aas and 12 established TMSs (Pi and Pittard 1996; Pi et al. 2002). Catalytic residues have been identified (Pi et al. 1993), and interhelical interactions have been proposed (Dogovski et al. 2003).