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2.A.3.10.15 S-adenosylmethionine uptake permease, SAM3 (also takes up polyamines, glutamate, lysine and the toxic S-adenosylmethionine analogue sinefungin) (Uemura et al., 2007; Zheng et al., 2007; Kashiwagi and Igarashi 2011).
Accession Number:	Q08986
Protein Name:	SAM3 aka YPL274w
Length:	587
Molecular Weight:	64354.00
Species:	Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:	12
Location¹ / Topology² / Orientation³:	Membrane¹ / Multi-pass membrane protein²
Substrate	lysine, polyamine macromolecule, S-adenosyl-L-methionine, glutamate(2-), sinefungin

DIP:	DIP-8874N
RefSeq:	NP_015049.1
Entrez Gene ID:	855854
Pfam:	PF00324
KEGG:	sce:YPL274W
Gene Ontology GO:0005783 C:endoplasmic reticulum GO:0016021 C:integral to membrane GO:0005886 C:plasma membrane GO:0005515 F:protein binding GO:0015489 F:putrescine transmembrane transporter activity GO:0000095 F:S-adenosylmethionine transmembrane transpor... GO:0015606 F:spermidine transmembrane transporter activity GO:0015847 P:putrescine transport GO:0015805 P:S-adenosylmethionine transport GO:0015848 P:spermidine transport GO:0055085 P:transmembrane transport
References (6) [1] “The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.” Bussey H.et.al. 9169875 [2] “Transport of sulfonium compounds. Characterization of the s-adenosylmethionine and s-methylmethionine permeases from the yeast Saccharomyces cerevisiae.” Rouillon A.et.al. 10497160 [3] “Global analysis of protein localization in budding yeast.” Huh W.-K.et.al. 14562095 [4] “Global analysis of protein expression in yeast.” Ghaemmaghami S.et.al. 14562106 [5] “Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.” Gruhler A.et.al. 15665377 [6] “A global topology map of the Saccharomyces cerevisiae membrane proteome.” Kim H.et.al. 16847258

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MDILKRGNES DKFTKIETES TTIPNDSDRS GSLIRRMKDS FKQSNLHVIP EDLENSEQTE 
61:	QEKIQWKLAS QPYQKVLSQR HLTMIAIGGT LGTGLFIGLG YSLASGPAAL LIGFLLVGTS 
121:	MFCVVQSAAE LSCQFPVSGS YATHVSRFID ESVGFTVATN YALAWLISFP SELIGCALTI 
181:	SYWNQTVNPA VWVAIFYVFI MVLNLFGVRG FAETEFALSI IKVIAIFIFI IIGIVLIAGG 
241:	GPNSTGYIGA KYWHDPGAFA KPVFKNLCNT FVSAAFSFGG SELVLLTSTE SKNISAISRA 
301:	AKGTFWRIAI FYITTVVIIG CLVPYNDPRL LSGSNSEDVS ASPFVIALSN TGSMGAKVSN 
361:	FMNVVILVAV VSVCNSCVYA SSRLIQALGA SGQLPSVCSY MDRKGRPLVG IGISGAFGLL 
421:	GFLVASKKED EVFTWLFALC SISSFFTWFC ICMSQIRFRM ALKAQGRSND EIAYKSILGV 
481:	YGGILGCVLN ALLIAGEIYV SAAPVGSPSS AEAFFEYCLS IPIMIVVYFA HRFYRRDWKH 
541:	FYIKRSEIDL DTGCSVENLE LFKAQKEAEE QLIASKPFYY KIYRFWC

2.A.3.10.15
S-adenosylmethionine uptake permease, SAM3 (also takes up polyamines, glutamate, lysine and the toxic S-adenosylmethionine analogue sinefungin) (Uemura et al., 2007; Zheng et al., 2007; Kashiwagi and Igarashi 2011).

Cross database links:

Gene Ontology

References (6)

External Searches:

Analyze:

2.A.3.10.15 S-adenosylmethionine uptake permease, SAM3 (also takes up polyamines, glutamate, lysine and the toxic S-adenosylmethionine analogue sinefungin) (Uemura et al., 2007; Zheng et al., 2007; Kashiwagi and Igarashi 2011).

Cross database links:

Gene Ontology

References (6)

External Searches:

Analyze:

2.A.3.10.15
S-adenosylmethionine uptake permease, SAM3 (also takes up polyamines, glutamate, lysine and the toxic S-adenosylmethionine analogue sinefungin) (Uemura et al., 2007; Zheng et al., 2007; Kashiwagi and Igarashi 2011).