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2.A.3.12.1 The plasma membrane polyamine (putrescine, spermidine):H⁺ uptake symporter, LmPOT1 (inhibited by pentamidine and protonophores) (Hasne and Ullmann, 2005; Zhang et al. 2022).
Accession Number:	Q5C8V6
Protein Name:	Polyamine transporter (Amino acid permease, putative)
Length:	803
Molecular Weight:	84779.00
Species:	Leishmania major [5664]
Number of TMSs:	12
Location¹ / Topology² / Orientation³:	Golgi apparatus membrane¹ / Multi-pass membrane protein²
Substrate	hydron, spermidine, putrescine

RefSeq:	XP_001687631.1
Entrez Gene ID:	5650231
Pfam:	PF00324
KEGG:	lma:LmjF14.0320
Gene Ontology GO:0016021 C:integral to membrane GO:0015171 F:amino acid transmembrane transporter activity GO:0006865 P:amino acid transport GO:0055085 P:transmembrane transport
References (2) [1] “Identification and characterization of a polyamine permease from the protozoan parasite Leishmania major.” Hasne M.P.et.al. 15632173 [2] “The genome of the kinetoplastid parasite, Leishmania major.” Ivens A.C.et.al. 16020728

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MRHARERSGA TDGAHAGDGD LVHASSQIKD VVSVNGISLG CGGIEDEKLA TAANGKSVRV 
61:	RRNVEVIFHP ELRRTKEVIR RPEWVRRAGE CVAHRGSLST IALFGIMFAN CVGGGYGFED 
121:	GIGSAGPLIT LIVCGILPWM WAFPTGLAVA ELSTAVPSNS GVLMWTNAAF PPFMSFMCIL 
181:	ATIFITFIGN ATYPNLTAEY AQQLGNLKLA PVAGVKVGVV ALCCILNCVG VEIVGSSSII 
241:	LCAITILPFT LLTVIQLFSK GFNRAVLYVD VKKVNWAEFF SILSWNYANI ENAGAVVEEV 
301:	ANPRRALPKA MMMLMLSTYV GYVMPMLAGV SAMGVDQDYS KWKAGHWPEV AKVIAGDWLK 
361:	YMLFAGALLS GIGFTLTSMC CTSRLLAGMG TMQMFPKKVS RVIGYYHPRL GTPIPAIFIN 
421:	SLVTLVFSVS MEFTSVVSLC QSIYCLRMLL IYASLVKMRI DYPNLPRPYA LPFSTCTTAL 
481:	VLLPAAAFSL MASIVSAMTS LGIGMALVGF VVVGSGVSWL YCRIFARNGF QGVIVQCEVS 
541:	SGDDAEAGAA DSANDSALSE GIFYADEERN SGEPVDDLLL GILPMPLAAP GPLASTVLPR 
601:	GSEVSSSQWH VRHGMTDRDA IGSQAGEEMI GMEYALQDGP STDIMVVNSS ATAHALGSST 
661:	AVCSPTSSFH TYRVACGVET TMRHRHRARS HGAGGGGGGA TNSGNYGPAV SGEESGEDPD 
721:	ITPAEHSGGG FTLSATGLPG QVLSTSPPQL ILSPQQVLLN VPAAGSWSSS RSPTPASGPR 
781:	SPILTSAINM STTRKPPPPP TSL

2.A.3.12.1
The plasma membrane polyamine (putrescine, spermidine):H⁺ uptake symporter, LmPOT1 (inhibited by pentamidine and protonophores) (Hasne and Ullmann, 2005; Zhang et al. 2022).

Cross database links:

Gene Ontology

References (2)

External Searches:

Analyze:

2.A.3.12.1The plasma membrane polyamine (putrescine, spermidine):H+ uptake symporter, LmPOT1 (inhibited by pentamidine and protonophores) (Hasne and Ullmann, 2005; Zhang et al. 2022).

Cross database links:

Gene Ontology

References (2)

External Searches:

Analyze:

2.A.3.12.1
The plasma membrane polyamine (putrescine, spermidine):H⁺ uptake symporter, LmPOT1 (inhibited by pentamidine and protonophores) (Hasne and Ullmann, 2005; Zhang et al. 2022).