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2.A.3.2.2
Cadaverine:lysine antiporter [Catalyzes cadaverine uptake via H+ symport (Km=21μM) and cadaverine export (Km=300 μM) via cadaverine:lysine antiport.] (Soksawatmaekhin et al., 2004). Modeling tools have been used to gain information about the structures and functions of CadB and PotE in E. coli (Tomitori et al., 2012).

Accession Number:P0AAE8
Protein Name:Probable cadaverine/lysine antiporter CadB aka B4132
Length:444
Molecular Weight:46665.00
Species:Escherichia coli [83333]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate cadaverine

Cross database links:

DIP: DIP-48089N
RefSeq: AP_004634.1    NP_418556.1   
Entrez Gene ID: 948654   
Pfam: PF00324   
BioCyc: EcoCyc:CADB-MONOMER    ECOL168927:B4132-MONOMER   
KEGG: ecj:JW4093    eco:b4132   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015171 F:amino acid transmembrane transporter activity
GO:0015297 F:antiporter activity
GO:0006865 P:amino acid transport
GO:0055085 P:transmembrane transport

References (6)

[1] “Identification of elements involved in transcriptional regulation of the Escherichia coli cad operon by external pH.”  Watson N.et.al.   1370290
[2] “Nucleotide sequence of the Escherichia coli cad operon: a system for neutralization of low extracellular pH.”  Meng S.-Y.et.al.   1556085
[3] “Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes.”  Burland V.D.et.al.   7610040
[4] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[5] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[6] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSSAKKIGLF ACTGVVAGNM MGSGIALLPA NLASIGGIAI WGWIISIIGA MSLAYVYARL 
61:	ATKNPQQGGP IAYAGEISPA FGFQTGVLYY HANWIGNLAI GITAVSYLST FFPVLNDPVP 
121:	AGIACIAIVW VFTFVNMLGG TWVSRLTTIG LVLVLIPVVM TAIVGWHWFD AATYAANWNT 
181:	ADTTDGHAII KSILLCLWAF VGVESAAVST GMVKNPKRTV PLATMLGTGL AGIVYIAATQ 
241:	VLSGMYPSSV MAASGAPFAI SASTILGNWA APLVSAFTAF ACLTSLGSWM MLVGQAGVRA 
301:	ANDGNFPKVY GEVDSNGIPK KGLLLAAVKM TALMILITLM NSAGGKASDL FGELTGIAVL 
361:	LTMLPYFYSC VDLIRFEGVN IRNFVSLICS VLGCVFCFIA LMGASSFELA GTFIVSLIIL 
421:	MFYARKMHER QSHSMDNHTA SNAH