2.A.3.3.3
Amino acid transporter, AAT1 or CAT1, of 594 aas and 14 TMSs. It is a high-affinity permease involved in the transport
of the cationic amino acids (e.g., arginine, lysine, histidine,
citrulline, valine, and glutamate). It transports mostly basic amino acids,
and, to a lesser extent, neutral and acidic amino acids. It probably functions as a
proton symporter. It transports histidine with a Km of 35 μM at Ph 4.5, the optimal pH for this system (Frommer et al. 1995).
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| Accession Number: | Q84MA5 |
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| Protein Name: | Cationic amino acid transporter 1 |
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| Length: | 594 |
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| Molecular Weight: | 64847.00 |
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| Species: | Arabidopsis thaliana (Mouse-ear cress) [3702] |
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| Number of TMSs: | 14 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
alpha-amino acid |
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1: MASGGGDDGL RRRGCSCTKD DFLPEESFQS MGNYLKALKE TPSRFMDRIM TRSLDSDEIN
61: EMKARSGHEM KKTLTWWDLM WFGIGAVIGS GIFVLTGLEA RNHSGPAVVL SYVVSGVSAM
121: LSVFCYTEFA VEIPVAGGSF AYLRVELGDF MAFIAAGNII LEYVVGGAAV ARSWTSYFAT
181: LLNHKPEDFR IIVHKLGEDY SHLDPIAVGV CAIICVLAVV GTKGSSRFNY IASIIHMVVI
241: LFVIIAGFTK ADVKNYSDFT PYGVRGVFKS AAVLFFAYIG FDAVSTMAEE TKNPGRDIPI
301: GLVGSMVVTT VCYCLMAVTL CLMQPYQQID PDAPFSVAFS AVGWDWAKYI VAFGALKGMT
361: TVLLVGAIGQ ARYMTHIARA HMMPPWLAQV NAKTGTPINA TVVMLAATAL IAFFTKLKIL
421: ADLLSVSTLF IFMFVAVALL VRRYYVTGET STRDRNKFLV FLGLILASST ATAVYWALEE
481: EGWIGYCITV PIWFLSTVAM KFLVPQARAP KIWGVPLVPW LPSASIAINI FLLGSIDTKS
541: FVRFAIWTGI LLIYYVLFGL HATYDTAKAT LKEKQALQKA EEGGVVADNS CSAT