TCDB » SEARCH

« See all members of the family

2.A.3.3.8 Low affinity cationic amino acid transporter 2 (CAT-2) (CAT2) (Solute carrier family 7 member 2) (Closs 1996). Elevated SLC7A2 expression is associated with an abnormal neuroinflammatory response and nitrosative stress in Huntington's disease (Gaudet et al. 2024).
Accession Number:	P52569
Protein Name:	Low affinity cationic amino acid transporter 2
Length:	658
Molecular Weight:	71673.00
Species:	Homo sapiens (Human) [9606]
Number of TMSs:	14
Location¹ / Topology² / Orientation³:	Membrane¹ / Multi-pass membrane protein²
Substrate	alpha-amino acid

Entrez Gene ID:	6542
KEGG:	hsa:6542
Gene Ontology GO:0005737 C:cytoplasm GO:0005887 C:integral to plasma membrane GO:0005624 C:membrane fraction GO:0015174 F:basic amino acid transmembrane transporter activity GO:0006520 P:cellular amino acid metabolic process GO:0006811 P:ion transport
References (6) [1] “Molecular cloning, tissue distribution, and chromosomal localization of human cationic amino acid transporter 2 (HCAT2).” Hoshide R.et.al. 8954799 [2] “Human cationic amino acid transporters hCAT-1, hCAT-2A, and hCAT-2B: three related carriers with distinct transport properties.” Closs E.I.et.al. 9174363 [3] “DNA sequence and analysis of human chromosome 8.” Nusbaum C.et.al. 16421571 [4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [5] “The full-ORF clone resource of the German cDNA consortium.” Bechtel S.et.al. 17974005 [6] “A quantitative atlas of mitotic phosphorylation.” Dephoure N.et.al. 18669648

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MIPCRAALTF ARCLIRRKIV TLDSLEDTKL CRCLSTMDLI ALGVGSTLGA GVYVLAGEVA 
61:	KADSGPSIVV SFLIAALASV MAGLCYAEFG ARVPKTGSAY LYTYVTVGEL WAFITGWNLI 
121:	LSYVIGTSSV ARAWSGTFDE LLSKQIGQFL RTYFRMNYTG LAEYPDFFAV CLILLLAGLL 
181:	SFGVKESAWV NKVFTAVNIL VLLFVMVAGF VKGNVANWKI SEEFLKNISA SAREPPSENG 
241:	TSIYGAGGFM PYGFTGTLAG AATCFYAFVG FDCIATTGEE VRNPQKAIPI GIVTSLLVCF 
301:	MAYFGVSAAL TLMMPYYLLD EKSPLPVAFE YVGWGPAKYV VAAGSLCALS TSLLGSIFPM 
361:	PRVIYAMAED GLLFKCLAQI NSKTKTPIIA TLSSGAVAAL MAFLFDLKAL VDMMSIGTLM 
421:	AYSLVAACVL ILRYQPGLSY DQPKCSPEKD GLGSSPRVTS KSESQVTMLQ RQGFSMRTLF 
481:	CPSLLPTQQS ASLVSFLVGF LAFLVLGLSV LTTYGVHAIT RLEAWSLALL ALFLVLFVAI 
541:	VLTIWRQPQN QQKVAFMVPF LPFLPAFSIL VNIYLMVQLS ADTWVRFSIW MAIGFLIYFS 
601:	YGIRHSLEGH LRDENNEEDA YPDNVHAAAE EKSAIQANDH HPRNLSSPFI FHEKTSEF

2.A.3.3.8
Low affinity cationic amino acid transporter 2 (CAT-2) (CAT2) (Solute carrier family 7 member 2) (Closs 1996). Elevated SLC7A2 expression is associated with an abnormal neuroinflammatory response and nitrosative stress in Huntington's disease (Gaudet et al. 2024).

Cross database links:

Gene Ontology

References (6)

External Searches:

Analyze:

2.A.3.3.8Low affinity cationic amino acid transporter 2 (CAT-2) (CAT2) (Solute carrier family 7 member 2) (Closs 1996). Elevated SLC7A2 expression is associated with an abnormal neuroinflammatory response and nitrosative stress in Huntington's disease (Gaudet et al. 2024).

Cross database links:

Gene Ontology

References (6)

External Searches:

Analyze:

2.A.3.3.8
Low affinity cationic amino acid transporter 2 (CAT-2) (CAT2) (Solute carrier family 7 member 2) (Closs 1996). Elevated SLC7A2 expression is associated with an abnormal neuroinflammatory response and nitrosative stress in Huntington's disease (Gaudet et al. 2024).