Search TCDB: (?)
TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.3.3.9
High affinity cationic amino acid transporter 1 (CAT-1) (CAT1, CTR1) (Ecotropic retroviral leukemia receptor homologue) (ERR), (SLC7a1) (System Y+ basic amino acid transporter) (Closs 1996). It takes up Arginine, Lysine and Ornithine. Its gene shows increased expression in various cancers such as colorectal cancer (CRC) (Okita et al. 2020). Treatment of a blood-brain barrier (BBB) mimetic with CAT-1 substrates as well as knockdown of CAT-1 expression yielded increases in leptin transport.Thus, an amino acid transporter is a regulator of leptin BBB transport in the iPSC-derived BBB model. These results provide insight into regulation of hormone transport across the BBB (Shi et al. 2022).  It is a possible drug target for pheochromocytomas and paragangliomas (PPGLs), rare neuroendocrine tumors (Vit et al. 2023).

Accession Number:P30825
Protein Name:High affinity cationic amino acid transporter 1
Length:629
Molecular Weight:67638.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate L-lysine, ornithine, arginine

Cross database links:

Entrez Gene ID: 6541   
KEGG: hsa:6541   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0015181 F:arginine transmembrane transporter activity
GO:0004872 F:receptor activity
GO:0006865 P:amino acid transport
GO:0006811 P:ion transport
GO:0032006 P:regulation of TOR signaling cascade
GO:0055085 P:transmembrane transport

References (6)

[1] “Molecular cloning and characterization of a novel human gene homologous to the murine ecotropic retroviral receptor.”  Yoshimoto T.et.al.   1718082
[2] “The human cationic amino acid transporter (ATRC1): physical and genetic mapping to 13q12-q14.”  Albritton L.M.et.al.   1348489
[3] “Identification of three cationic amino acid transporters in placental trophoblast: cloning, expression, and characterization of hCAT-1.”  Kamath S.G.et.al.   10485994
[4] “The DNA sequence and analysis of human chromosome 13.”  Dunham A.et.al.   15057823
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[6] “Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.”  Wollscheid B.et.al.   19349973

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence 
1:	MGCKVLLNIG QQMLRRKVVD CSREETRLSR CLNTFDLVAL GVGSTLGAGV YVLAGAVARE 
61:	NAGPAIVISF LIAALASVLA GLCYGEFGAR VPKTGSAYLY SYVTVGELWA FITGWNLILS 
121:	YIIGTSSVAR AWSATFDELI GRPIGEFSRT HMTLNAPGVL AENPDIFAVI IILILTGLLT 
181:	LGVKESAMVN KIFTCINVLV LGFIMVSGFV KGSVKNWQLT EEDFGNTSGR LCLNNDTKEG 
241:	KPGVGGFMPF GFSGVLSGAA TCFYAFVGFD CIATTGEEVK NPQKAIPVGI VASLLICFIA 
301:	YFGVSAALTL MMPYFCLDNN SPLPDAFKHV GWEGAKYAVA VGSLCALSAS LLGSMFPMPR 
361:	VIYAMAEDGL LFKFLANVND RTKTPIIATL ASGAVAAVMA FLFDLKDLVD LMSIGTLLAY 
421:	SLVAACVLVL RYQPEQPNLV YQMASTSDEL DPADQNELAS TNDSQLGFLP EAEMFSLKTI 
481:	LSPKNMEPSK ISGLIVNIST SLIAVLIITF CIVTVLGREA LTKGALWAVF LLAGSALLCA 
541:	VVTGVIWRQP ESKTKLSFKV PFLPVLPILS IFVNVYLMMQ LDQGTWVRFA VWMLIGFIIY 
601:	FGYGLWHSEE ASLDADQART PDGNLDQCK