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| Accession Number: | Q9UHI5 |
| Protein Name: | Large neutral amino acids transporter small subunit 2 |
| Length: | 535 |
| Molecular Weight: | 58382.00 |
| Species: | Homo sapiens (Human) [9606] |
| Number of TMSs: | 12 |
| Location1 / Topology2 / Orientation3: | Cytoplasm1 |
| Substrate | 3,3',5-triiodo-L-thyronine, alanine, serine, cystine, methionine, asparagine, L-threonine, L-isoleucine, glutamine, proline, valine, leucine, glycine, phenylalanine, tryptophan, tyrosine, ditritium |
Cross database links:
| Entrez Gene ID: | 23428 |
|---|---|
| KEGG: | hsa:23428 |
Gene Ontology
GO:0016323
C:basolateral plasma membrane
GO:0005737
C:cytoplasm
GO:0005887
C:integral to plasma membrane
GO:0015179
F:L-amino acid transmembrane transporter activity
GO:0015175
F:neutral amino acid transmembrane transporter activity
GO:0015101
F:organic cation transmembrane transporter activity
GO:0042605
F:peptide antigen binding
GO:0019534
F:toxin transporter activity
GO:0007596
P:blood coagulation
GO:0006520
P:cellular amino acid metabolic process
GO:0050900
P:leukocyte migration
GO:0055065
P:metal ion homeostasis
GO:0009636
P:response to toxin
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References (12)[1] “Identification of a membrane protein, LAT-2, that co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids.” Pineda M.et.al. 10391915 [2] “LAT2, a new basolateral 4F2hc/CD98-associated amino acid transporter of kidney and intestine.” Rossier G.et.al. 10574970 [3] “SLC7A7, encoding a putative permease-related protein, is mutated in patients with lysinuric protein intolerance.” Borsani G.et.al. 10080183 [4] “Reabsorption of neutral amino acids mediated by amino acid transporter LAT2 and TAT1 in the basolateral membrane of proximal tubule.” Park S.Y.et.al. 15918515 [5] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [7] “Association of 4F2hc with light chains LAT1, LAT2 or y+LAT2 requires different domains.” Broeer A.et.al. 11311135 [8] “Transport of a neurotoxicant by molecular mimicry: the methylmercury-L-cysteine complex is a substrate for human L-type large neutral amino acid transporter (LAT) 1 and LAT2.” Simmons-Willis T.A.et.al. 12117417 [9] “CD98 and intracellular adhesion molecule I regulate the activity of amino acid transporter LAT-2 in polarized intestinal epithelia.” Liu X.et.al. 12716892 [10] “Identification and functional characterization of a Na(+)-independent large neutral amino acid transporter (LAT2) on ARPE-19 cells.” Gandhi M.D.et.al. 15081149 | |
External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MEEGARHRNN TEKKHPGGGE SDASPEAGSG GGGVALKKEI GLVSACGIIV GNIIGSGIFV 61: SPKGVLENAG SVGLALIVWI VTGFITVVGA LCYAELGVTI PKSGGDYSYV KDIFGGLAGF 121: LRLWIAVLVI YPTNQAVIAL TFSNYVLQPL FPTCFPPESG LRLLAAICLL LLTWVNCSSV 181: RWATRVQDIF TAGKLLALAL IIIMGIVQIC KGEYFWLEPK NAFENFQEPD IGLVALAFLQ 241: GSFAYGGWNF LNYVTEELVD PYKNLPRAIF ISIPLVTFVY VFANVAYVTA MSPQELLASN 301: AVAVTFGEKL LGVMAWIMPI SVALSTFGGV NGSLFTSSRL FFAGAREGHL PSVLAMIHVK 361: RCTPIPALLF TCISTLLMLV TSDMYTLINY VGFINYLFYG VTVAGQIVLR WKKPDIPRPI 421: KINLLFPIIY LLFWAFLLVF SLWSEPVVCG IGLAIMLTGV PVYFLGVYWQ HKPKCFSDFI 481: ELLTLVSQKM CVVVYPEVER GSGTEEANED MEEQQQPMYQ PTPTKDKDVA GQPQP