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|---|---|
| Accession Number: | Q9UM01 |
| Protein Name: | Y+L amino acid transporter 1 |
| Length: | 511 |
| Molecular Weight: | 55991.00 |
| Species: | Homo sapiens (Human) [9606] |
| Number of TMSs: | 14 |
| Location1 / Topology2 / Orientation3: | Basolateral cell membrane1 / Multi-pass membrane protein2 |
| Substrate | alpha-amino acid, L-lysine, arginine, histidine |
Cross database links:
| Entrez Gene ID: | 9056 |
|---|---|
| KEGG: | hsa:9056 |
Gene Ontology
GO:0016323
C:basolateral plasma membrane
GO:0005887
C:integral to plasma membrane
GO:0015171
F:amino acid transmembrane transporter activity
GO:0006865
P:amino acid transport
GO:0007596
P:blood coagulation
GO:0006520
P:cellular amino acid metabolic process
GO:0006811
P:ion transport
GO:0050900
P:leukocyte migration
GO:0006461
P:protein complex assembly
GO:0055085
P:transmembrane transport
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References (20)[1] “Identification and characterization of a membrane protein (y+L amino acid transporter-1) that associates with 4F2hc to encode the amino acid transport activity y+L. A candidate gene for lysinuric protein intolerance.” Torrents D.et.al. 9829974 [2] “Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family.” Pfeiffer R.et.al. 9878049 [3] “SLC7A7, encoding a putative permease-related protein, is mutated in patients with lysinuric protein intolerance.” Borsani G.et.al. 10080183 [4] “SLC7A7 genomic structure and novel variants in three Japanese lysinuric protein intolerance families.” Noguchi A.et.al. 10737982 [5] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [7] “Arginine transport through system y(+)L in cultured human fibroblasts: normal phenotype of cells from LPI subjects.” Dall'Asta V.et.al. 11078698 [8] “Two-way arginine transport in human endothelial cells: TNF-alpha stimulation is restricted to system y(+).” Sala R.et.al. 11742806 [9] “Nitric oxide synthesis requires activity of the cationic and neutral amino acid transport system y+L in human umbilical vein endothelium.” Arancibia-Garavilla Y.et.al. 14603368 [10] “INFgamma stimulates arginine transport through system y+L in human monocytes.” Rotoli B.M.et.al. 15280038 [11] “Activation of classical protein kinase C decreases transport via systems y+ and y+L.” Rotmann A.et.al. 17329401 [12] “Ornithine transport via cationic amino acid transporter-1 is involved in ornithine cytotoxicity in retinal pigment epithelial cells.” Kaneko S.et.al. 17197568 [13] “Identification of SLC7A7, encoding y+LAT-1, as the lysinuric protein intolerance gene.” Torrents D.et.al. 10080182 [14] “Structure of the SLC7A7 gene and mutational analysis of patients affected by lysinuric protein intolerance.” Sperandeo M.P.et.al. 10631139 [15] “Functional analysis of novel mutations in y+LAT-1 amino acid transporter gene causing lysinuric protein intolerance (LPI).” Mykkaenen J.et.al. 10655553 [16] “Five novel SLC7A7 variants and y+L gene-expression pattern in cultured lymphoblasts from Japanese patients with lysinuric protein intolerance.” Shoji Y.et.al. 12402335 [17] “A y(+)LAT-1 mutant protein interferes with y(+)LAT-2 activity: implications for the molecular pathogenesis of lysinuric protein intolerance.” Sperandeo M.P.et.al. 15756301 [18] “Lysinuric protein intolerance: identification and functional analysis of mutations of the SLC7A7 gene.” Sperandeo M.P.et.al. 15776427 | |
External Searches:
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| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MVDSTEYEVA SQPEVETSPL GDGASPGPEQ VKLKKEISLL NGVCLIVGNM IGSGIFVSPK 61: GVLIYSASFG LSLVIWAVGG LFSVFGALCY AELGTTIKKS GASYAYILEA FGGFLAFIRL 121: WTSLLIIEPT SQAIIAITFA NYMVQPLFPS CFAPYAASRL LAAACICLLT FINCAYVKWG 181: TLVQDIFTYA KVLALIAVIV AGIVRLGQGA STHFENSFEG SSFAVGDIAL ALYSALFSYS 241: GWDTLNYVTE EIKNPERNLP LSIGISMPIV TIIYILTNVA YYTVLDMRDI LASDAVAVTF 301: ADQIFGIFNW IIPLSVALSC FGGLNASIVA ASRLFFVGSR EGHLPDAICM IHVERFTPVP 361: SLLFNGIMAL IYLCVEDIFQ LINYYSFSYW FFVGLSIVGQ LYLRWKEPDR PRPLKLSVFF 421: PIVFCLCTIF LVAVPLYSDT INSLIGIAIA LSGLPFYFLI IRVPEHKRPL YLRRIVGSAT 481: RYLQVLCMSV AAEMDLEDGG EMPKQRDPKS N