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2.A.30.1.13 KCl symporter, KCC1. Water can be cotransported with KCl (Mollajew et al., 2010). KCCs are regulated through an N-terminal plug of the ion pathway (Kock Flygaard et al. 2021). KCC1 shows anion specificity in the order: Cl^- > SCN^- = Br^- > PO₄^-3 > I^-(Mercado et al. 2000).
Accession Number:	Q63632
Protein Name:	SLC12A4 or KCC1
Length:	1085
Molecular Weight:	120628.00
Species:	Rattus norvegicus (Rat) [10116]
Number of TMSs:	12
Location¹ / Topology² / Orientation³:	Membrane¹ / Multi-pass membrane protein²
Substrate	chloride, bromide, iodide, water, isothiocyanato group, inorganic phosphate

RefSeq:	NP_062102.1
Entrez Gene ID:	29501
Pfam:	PF00324 PF03522
KEGG:	rno:29501
Gene Ontology GO:0016021 C:integral to membrane GO:0015377 F:cation:chloride symporter activity GO:0006821 P:chloride transport GO:0006813 P:potassium ion transport GO:0006814 P:sodium ion transport GO:0055085 P:transmembrane transport
References (2) [1] “Molecular cloning and functional expression of the K-Cl cotransporter from rabbit, rat, and human. A new member of the cation-chloride cotransporter family.” Gillen C.M.et.al. 8663127 [2] “Mouse K-Cl cotransporter KCC1: cloning, mapping, pathological expression, and functional regulation.” Su W.et.al. 10564083

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MPHFTVVPVD GPRRGDYDNL EGLSWVDYGE RAEREDSDGQ GNHRENSPFL SPLDASRGND 
61:	YYDRNLALFE EELDIRPKVS SLLGKLVSYT NLTQGAKEHE EAESGEGGRR RAAKAPSMGT 
121:	LMGVYLPCLQ NIFGVILFLR LTWMVGTAGV LQALLIVLIC CCCTLLTAIS MSAIATNGVV 
181:	PAGGSYFMIS RSLGPEFGGA VGLCFYLGTT FAAAMYILGA IEILLTYIAP PAAIFYPSGT 
241:	HDMSSATLNN MRVYGTIFLT FMTLVVFVGV KYVNKFASLF LACVIISILS IYVGGIKSAF 
301:	DPPVFPVCML GNRTLSRDQF DICAKTVVVD NETVATRLWT FFCHSPNLTA DSCDPYFLLN 
361:	NVTEIPGIPG AAAGVLQENL WSAYLEKGEV VEKHGLPSTD TLGLKESLSL YVVADIATSF 
421:	TVLVGIFFPS VTGIMAGSNR SGDLRDAQKS IPVGTILAIV TTSLVYFSSV ILFGACIEGV 
481:	VLRDKYGDGV SRNLVVGTLA WPSPWVIVVG SFFSTCGAGL QSLTGAPRLL QAIAKDNIIP 
541:	FLRVFGHGKA NGEPTWALLL TALIAELGIL IASLDMVAPI LSMFFLMCYL FVNLACAVQT 
601:	LLRTPNWRPR FKYYHWALSF LGMSLCLALM FVSSWYYALV AMVIAGMIYK YIEYQGAEKE 
661:	WGDGIRGLSL SAARYALLRL EEGPPHTKNW RPQLLVLLKL DEDLHVKYPR LLTFASQLKA 
721:	GKGLTIVGSV IQGSFLESYG EAQAAEQTIK NMMEIEKVKG FCQVVVASKV REGLAHLIQS 
781:	CGLGGMRHNS VVLGWPYGWR QSEDPRAWKT FIDTVRCTTA AHLALLVPKN IAFYPSNHER 
841:	YLEGHIDVWW IVHDGGMLML LPFLLRQHKV WKKCRMRIFT VAQMDDNSIQ MKKDLAIFLY 
901:	HLRLEAEVEV VEMHNSDISA YTYERTLMME QRSQMLRQMR LTKTERDREA QLVKDRHSAL 
961:	RLESLYSDEE DESVTGADKI QMTWTRDKYM AEPWDPSHAP DNFRELVHIK PDQSNVRRMH 
1021:	TAVKLNEVIV TRSHDARLVL LNMPGPPKNS EGDENYMEFL EVLTEGLERV LLVRGGGREV 
1081:	ITIYS

2.A.30.1.13
KCl symporter, KCC1. Water can be cotransported with KCl (Mollajew et al., 2010). KCCs are regulated through an N-terminal plug of the ion pathway (Kock Flygaard et al. 2021). KCC1 shows anion specificity in the order: Cl^- > SCN^- = Br^- > PO₄^-3 > I^-(Mercado et al. 2000).

Cross database links:

Gene Ontology

References (2)

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2.A.30.1.13KCl symporter, KCC1. Water can be cotransported with KCl (Mollajew et al., 2010). KCCs are regulated through an N-terminal plug of the ion pathway (Kock Flygaard et al. 2021). KCC1 shows anion specificity in the order: Cl- > SCN- = Br- > PO4-3 > I- (Mercado et al. 2000).

Cross database links:

Gene Ontology

References (2)

External Searches:

Analyze:

2.A.30.1.13
KCl symporter, KCC1. Water can be cotransported with KCl (Mollajew et al., 2010). KCCs are regulated through an N-terminal plug of the ion pathway (Kock Flygaard et al. 2021). KCC1 shows anion specificity in the order: Cl^- > SCN^- = Br^- > PO₄^-3 > I^-(Mercado et al. 2000).