2.A.30.1.21
K+/Cl- Cotransporter, Kcc-2, of 1129 aas and probably 11 TMSs in a 5 + 6 TMS arrangement. The expression of its gene was responsive to the presence of Ivermectin at 10 to 100 nM concentrations (Dube et al. 2023).
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| Accession Number: | H2KZC3 |
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| Protein Name: | K+/Cl- Cotransporter |
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| Length: | 1129 |
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| Molecular Weight: | 124098.00 |
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| Species: | Caenorhabditis elegans [6239] |
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| Number of TMSs: | 12 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
chloride, potassium(1+) |
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1: MSGGRFRVQS VADGGGGGAG SVGALDSVSD SNLAVNSATK KEITNKAHDF EPEPTSSTST
61: NTVTSRRSSG GSGSGLGPAS KKPPNMHINI PTDEGAERIP LCEQHSPLAL YEQDYDTQGQ
121: KIGTMLRKLS VYNATEATSV EADEKPKAAA AKMGTIMGVF LPCLQNIFGV LFFIRLAWII
181: GTAGVFQAFF VVLTCVSVTF LTSISLSAIA TNGVVPSGGP YYMISRNLGP ELGGAVGILF
241: YLGTTIAASM YITGAIEILL LYIYPQAKLF DDIYHNFRVL GTVLLLILGL IVMAGVKFVN
301: RCALPLVIVV ILCILSAILG VFVRYDGSDS LKFCMVGDRP VDLSTYFEKT QVQPNCTADG
361: LQDLFCSTNG TCDHYYDRMK NIKVWKSSGM PAIREERAIK GIASGVFFDN LWPKYLRAGE
421: VLSKDRKDKG DLNRGGHPSY IYAESVTNFM ILVGVFFPSA TGIMAGSNRS GNLRDAAKSI
481: PLGTLAAQNF SSFIYLLGVV LFGASVSEMF IRDKYGRSAM GKLIISEISW PFPQVILFGC
541: FMSTAGAGMQ SLTGAPRLLQ AIAADDVLPF LKPFRKMDSR GEPIRAILLT LAICECGILI
601: AVIENITALI TQFFLMCYLG VNAACALQSL LKSPGWRPGF RYFHWSLSMI GAILCVAVMF
661: ISAWHFALFA IIIGAGVYKY IEYAGAEKEW GDGLRGLGLS AARFALLNLD DKPQHSRNWR
721: PQLLVLAPDV ESANTNGILS FVSQLKAGKG LTLVAHCMEG EYADNYLKAQ AVQEKLKAVV
781: KKNKIKGFCD VLVTSNVIEG ISCLVQTSGL GGMRHNTVVL SWPNDWKAEQ EWVVANKFVS
841: AIRAISAAKC AIMVPKYAEK FPANGTKVSG FIDVWWVVHD GGLLMLLPFL LRQHKTWKNT
901: TVRLFAIAQM EDNNVQMKTD LEKFLYHLRI DAAVNVIEMT DSDISDYTYE RTMKMEERNQ
961: YLKNLNKSDR DKDIQNHLEI VTRERKLSRI NEEAPAVVPE QRNLEVVDEE QEDGKSENGS
1021: AKIEHKGVRF SDDEDSKEVK VGNGTLERDR EERQRKRRYN VHKMHTAVKL NELMRQKSSD
1081: AQLVFVNLPG PPDADSDSYY MDFIEALTEG LDRVLLVRGT GAEVVTIYS