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| Accession Number: | Q25479 |
| Protein Name: | NKCL |
| Length: | 1060 |
| Molecular Weight: | 117393.00 |
| Species: | Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm) [7130] |
| Number of TMSs: | 13 |
| Location1 / Topology2 / Orientation3: | Membrane1 / Multi-pass membrane protein2 |
| Substrate | |
Cross database links:
| Pfam: | PF00324 |
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Gene Ontology
GO:0016021
C:integral to membrane
GO:0015377
F:cation:chloride symporter activity
GO:0006821
P:chloride transport
GO:0006813
P:potassium ion transport
GO:0006814
P:sodium ion transport
GO:0055085
P:transmembrane transport
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References (1)[1] “Molecular cloning of a putative Na(+)-K(+)-2Cl-cotransporter from the Malpighian tubules of the tobacco hornworm, Manduca sexta.” Reagan J.D.et.al. 7550244
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External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MNDENRFNVS AVEGESKKNG IHMGANIITR PLRSSVENVE RGVAPNSQSE GWHHESGWKR 61: RRSLAQLTRE ALPRMENYRN SKRALKRPSL GELHGDHLIT EEDEKDQNHR DTKSPTPAVG 121: IKLGWIQGVF IPCLLNIWGV MLFLRLSWVV SQAGIGLSLV IIAISAIVCV ITTLSMSAIC 181: TNGEVKGGGI YYIISRSLGP EFGASVGIIF AFANAVAASM NTIGFCDSLN DLLRSNGLKI 241: TEDPINDVRI VGTVALLVMC IICAIGMDWE SKAQNFLIAI IVGAMVDFVV GTIMGPKDNS 301: EIAKGFVGLS SATFVENFKS DFRFSEKLDQ NFFSVFAIFF PSVTGIQAGA NISGDLKDPA 361: SAIPKGTLLA LLISMVSYTL MVLFAGGGAL RDASGNITDL LIVNGTVTDY SSVSLCALNN 421: TCEYGLHNSY SVMQLMSAWG PFIYGGCWAA TLSTALTNLL SVPRLIQALG VDRIYPGLIF 481: FSKPYGRHGE PYRGYVLTFF VSLLFLLIAD LNTIAPLISN FYLASYALIN FCTFHRALVR 541: PLGWRPTFRY YNMWLSLAGF LMCVAIMLLV HWVMSLVTFA IFFTLYLIVH YRRPDVNWGS 601: STQAQMYKTA LSSAHALART GEHVKNYWPQ LLVLAGRPQA RPALVDLGNL ISKAGSLMIV 661: GDISQEKLSY KVRSARARSD DEWLRGRKVR AFCSRVHGFS FEPGARALVQ GSGVGRLAPN 721: VLLMGYKSDW TTCPANDLVS YFNVLHTAFE NRLAVAIVRV SGGLDYSAVV SEGAEEGAAG 781: SLTATSSSGE LRVRRDGLIM HADSDLDIRD TQPKHNLSNL LTLTTSRSFT ISECKEKDKK 841: KKERKPNDMH RQIVYNTASG LELSKFQLAQ MSLFQKKQES GTLDVWWLYD DGGLTILLPY 901: IISQRSAWAN CKLRIFALAN RLHEMELEER NMANLLAKFR IDYSSLTMVQ DITDPPQPET 961: KALFDETIKK FTEESASPDC RISDMELQTL AVKTNRQLRL RELLLANSKD ARLVVMSLPM 1021: PRKGSISAPL YMAWLEMMSR DLPPMLFVRG NHTSVLTFYS