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|---|---|
| Accession Number: | P04920 |
| Protein Name: | AE2 |
| Length: | 1241 |
| Molecular Weight: | 137009.00 |
| Species: | Homo sapiens (Human) [9606] |
| Number of TMSs: | 14 |
| Location1 / Topology2 / Orientation3: | Membrane1 / Multi-pass membrane protein2 |
| Substrate | chloride, hydrogencarbonate |
Cross database links:
| RefSeq: | NP_003031.3 |
|---|---|
| Entrez Gene ID: | 6522 |
| Pfam: | PF07565 PF00955 |
| OMIM: |
109280 gene |
| KEGG: | hsa:6522 hsa:6522 |
Gene Ontology
GO:0016021
C:integral to membrane
GO:0005624
C:membrane fraction
GO:0005452
F:inorganic anion exchanger activity
GO:0006820
P:anion transport
GO:0016323
C:basolateral plasma membrane
GO:0005886
C:plasma membrane
GO:0008509
F:anion transmembrane transporter activity
GO:0015108
F:chloride transmembrane transporter activity
GO:0015701
P:bicarbonate transport
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References (16)[1] “Complete nucleotide sequence of band 3 related anion transport protein AE2 from human kidney.” Gehrig H.et.al. 1562608 [2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [4] “Cloning and structural characterization of a human non-erythroid band 3-like protein.” Demuth D.R.et.al. 3015590 [5] “A quantitative atlas of mitotic phosphorylation.” Dephoure N.et.al. 18669648 [6] “Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.” Gauci S.et.al. 19413330 [7] “Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.” Mayya V.et.al. 19690332 [8] “Complete nucleotide sequence of band 3 related anion transport protein AE2 from human kidney.” Gehrig H.et.al. 1562608 [9] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [10] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [11] “Cloning and structural characterization of a human non-erythroid band 3-like protein.” Demuth D.R.et.al. 3015590 [12] “Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks.” Wolf-Yadlin A.et.al. 17389395 | |
External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MSSAPRRPAK GADSFCTPEP ESLGPGTPGF PEQEEDELHR TLGVERFEEI LQEAGSRGGE 61: EPGRSYGEED FEYHRQSSHH IHHPLSTHLP PDARRRKTPQ GPGRKPRRRP GASPTGETPT 121: IEEGEEDEDE ASEAEGARAL TQPSPVSTPS SVQFFLQEDD SADRKAERTS PSSPAPLPHQ 181: EATPRASKGA QAGTQVEEAE AEAVAVASGT AGGDDGGASG RPLPKAQPGH RSYNLQERRR 241: IGSMTGAEQA LLPRVPTDEI EAQTLATADL DLMKSHRFED VPGVRRHLVR KNAKGSTQSG 301: REGREPGPTP RARPRAPHKP HEVFVELNEL LLDKNQEPQW RETARWIKFE EDVEEETERW 361: GKPHVASLSF RSLLELRRTL AHGAVLLDLD QQTLPGVAHQ VVEQMVISDQ IKAEDRANVL 421: RALLLKHSHP SDEKDFSFPR NISAGSLGSL LGHHHGQGAE SDPHVTEPLM GGVPETRLEV 481: ERERELPPPA PPAGITRSKS KHELKLLEKI PENAEATVVL VGCVEFLSRP TMAFVRLREA 541: VELDAVLEVP VPVRFLFLLL GPSSANMDYH EIGRSISTLM SDKQFHEAAY LADEREDLLT 601: AINAFLDCSV VLPPSEVQGE ELLRSVAHFQ RQMLKKREEQ GRLLPTGAGL EPKSAQDKAL 661: LQMVEAAGAA EDDPLRRTGR PFGGLIRDVR RRYPHYLSDF RDALDPQCLA AVIFIYFAAL 721: SPAITFGGLL GEKTQDLIGV SELIMSTALQ GVVFCLLGAQ PLLVIGFSGP LLVFEEAFFS 781: FCSSNHLEYL VGRVWIGFWL VFLALLMVAL EGSFLVRFVS RFTQEIFAFL ISLIFIYETF 841: YKLVKIFQEH PLHGCSASNS SEVDGGENMT WAGARPTLGP GNRSLAGQSG QGKPRGQPNT 901: ALLSLVLMAG TFFIAFFLRK FKNSRFFPGR IRRVIGDFGV PIAILIMVLV DYSIEDTYTQ 961: KLSVPSGFSV TAPEKRGWVI NPLGEKSPFP VWMMVASLLP AILVFILIFM ETQITTLIIS 1021: KKERMLQKGS GFHLDLLLIV AMGGICALFG LPWLAAATVR SVTHANALTV MSKAVAPGDK 1081: PKIQEVKEQR VTGLLVALLV GLSIVIGDLL RQIPLAVLFG IFLYMGVTSL NGIQFYERLH 1141: LLLMPPKHHP DVTYVKKVRT LRMHLFTALQ LLCLALLWAV MSTAASLAFP FILILTVPLR 1201: MVVLTRIFTD REMKCLDANE AEPVFDEREG VDEYNEMPMP V