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| Accession Number: | Q9R1N3 |
| Protein Name: | NBCn1-D aka NBC2 |
| Length: | 1218 |
| Molecular Weight: | 135954.00 |
| Species: | Rattus norvegicus (Rat) [10116] |
| Number of TMSs: | 10 |
| Location1 / Topology2 / Orientation3: | Basolateral cell membrane1 / Multi-pass membrane protein2 |
| Substrate | sodium(1+), hydrogencarbonate |
Cross database links:
| RefSeq: | NP_478118.1 |
|---|---|
| Entrez Gene ID: | 117955 |
| Pfam: | PF07565 PF00955 |
| KEGG: | rno:117955 |
Gene Ontology
GO:0016324
C:apical plasma membrane
GO:0016323
C:basolateral plasma membrane
GO:0031410
C:cytoplasmic vesicle
GO:0016021
C:integral to membrane
GO:0032420
C:stereocilium
GO:0005452
F:inorganic anion exchanger activity
GO:0015293
F:symporter activity
GO:0006820
P:anion transport
GO:0006814
P:sodium ion transport
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References (10)[1] “An electroneutral sodium/bicarbonate cotransporter NBCn1 and associated sodium channel.” Choi I.et.al. 10850716 [2] “Immunoelectron microscopic localization of NBC3 sodium-bicarbonate cotransporter in rat kidney.” Kwon T.-H.et.al. 10662737 [3] “Immunolocalization of electroneutral Na-HCO(3)(-) cotransporter in rat kidney.” Vorum H.et.al. 11053051 [4] “Immunolocalization of NBC3 and NHE3 in the rat epididymis: colocalization of NBC3 and the vacuolar H+-ATPase.” Pushkin A.et.al. 10975418 [5] “The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO3- salvage transporter human Na+-HCO3-cotransport isoform 3.” Park M.et.al. 12403779 [6] “NBCn1 is a basolateral Na+-HCO3- cotransporter in rat kidney inner medullary collecting ducts.” Praetorius J.et.al. 15075186 [7] “Basolateral Na+-dependent HCO3- transporter NBCn1-mediated HCO3-influx in rat medullary thick ascending limb.” Odgaard E.et.al. 14673192 [8] “Scaffold protein harmonin (USH1C) provides molecular links between Usher syndrome type 1 and type 2.” Reiners J.et.al. 16301216 [9] “Molecular and functional characterization of the electroneutral Na/HCO3 cotransporter NBCn1 in rat hippocampal neurons.” Cooper D.S.et.al. 15718246 [10] “An anti-NH2-terminal antibody localizes NBCn1 to heart endothelia and skeletal and vascular smooth muscle cells.” Damkier H.H.et.al. 16126812
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External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MEADGAGEQM RPLLTRGPDE EAVVDLGKTS STVNTKFEKE ELESHRAVYV GVHVPFSKES 61: RRRHRHRGHK HHHRRRKDKD SDKEDGRESP SYDTPSQRVQ FILGTEDDDE EHIPHDLFTE 121: MDELCYRDGE EYEWKETARW LKFEEDVEDG GDRWSKPYVA TLSLHSLFEL RSCILNGTVM 181: LDMRASTLDE IADMVLDNMI ASGQLDDSIR ENVREALLKR HHHQNEKRFT SRIPLVRSFA 241: DIGKKHSDPH LLERNGEGLS ASRHSLRTGL SASNLSLRGE SPLSLLLSHL LPSSRAGTPA 301: GSRCTTPVPT PQNSPPSSPS LSRLTSRSSQ QTQPQAPEVL VSPDRDDIPR VVIHPPEEDI 361: EALKGQEQKN EENTDFTPGI LASPQSAPGN LDSSKSGEVK GNGSGGSREN STVDFSKVDM 421: NFMRKIPTGA EASNVLVGEV DFLERPIIAF VRLAPAVLLS GLTEVPVPTR FLFLLLGPAG 481: KAPQYHEIGR SIATLMTDEI FHDVAYKAKD RNDLLSGIDE FLDQVTVLPP GEWDPSIRIE 541: PPKSVPSQEK RKIPAFPNGS APVSADPPKE ADHHAGPELQ RTGRLFGGLI LDIKRKAPFF 601: LSDFKDALSL QCLASILFLY CACMSPVITF GGLLGEATEG RISAIESLFG ASLTGIAYSL 661: FAGQPLTILG STGPVLVFEK ILFKFCRDYH LSYLSLRTSI GLWTSFLCIV LVATDASSLV 721: CYITRFTEEA FAALICIIFI YEALEKLFHL GEIYAFNMHN NLDALTSYTC VCAEPSNPSN 781: ETVELWERKN VTAASISWAN LTVSECKTFH GMFVGSACGP HGPYVPDVLF WCVVLFFTTF 841: FLSSFLKQFK TKRYFPTKVR STISDFAVFL TIVIMVAIDY LVGIPSPKLH VPEKFEPTDP 901: SRGWIISPLG DNPWWTLLIA AVPALLCTIL IFMDQQITAV IINRKEHKLK KGAGYHLDLL 961: MVAVMLGVCS IMGLPWFVAA TVLSISHVNS LKVESECSAP GEQPKFLGIR EQRVTGLMIF 1021: ILMGLSVFMT SVLKFIPMPV LYGVFLYMGV SSLKGIQFFD RIKLFGMPAK HQPDLIYLRY 1081: VPLWKVHVFT VVQLTCLVLL WVIKASAAAV VFPMMVLALV FVRKLMDLCF TKRELSWLDD 1141: LMPESKKKKE DDKKKKEKEE AERMLQGDGD TVHLPFERGS LLQIPVKTLK YSPEKPVSVT 1201: INFEDEPSKK YMDAETSL