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2.A.31.2.8
Electrogenic HCO3-:Na+ symporter, NBCe2 (3:1 stoichiometry) (Millar and Brown, 2008)

Accession Number:Q9BY07
Protein Name:NBCe2
Length:1137
Molecular Weight:126255.00
Species:Mus Musculus (Mouse) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Apical cell membrane1 / Multi-pass membrane protein2
Substrate bicarbonate, Na+

Cross database links:

RefSeq: NP_067019.3    NP_597812.1   
Entrez Gene ID: 57835   
Pfam: PF07565    PF00955   
OMIM: 606757  gene
KEGG: hsa:57835    hsa:57835   

Gene Ontology

GO:0016324 C:apical plasma membrane
GO:0016021 C:integral to membrane
GO:0005452 F:inorganic anion exchanger activity
GO:0008510 F:sodium:bicarbonate symporter activity
GO:0015701 P:bicarbonate transport
GO:0006814 P:sodium ion transport
GO:0005886 C:plasma membrane

References (16)

[1] “Cloning, characterization and chromosomal assignment of NBC4, a new member of the sodium bicarbonate cotransporter family.”  Pushkin A.et.al.   10978526
[2] “Two C-terminal variants of NBC4, a new member of the sodium bicarbonate cotransporter family: cloning, characterization, and localization.”  Pushkin A.et.al.   11087115
[3] “Genomic organization of the DCTN1-SLC4A5 locus encoding both NBC4 and p150(Glued).”  Pushkin A.et.al.   12063394
[4] “Functional characterization of NBC4: a new electrogenic sodium-bicarbonate cotransporter.”  Sassani P.et.al.   11788353
[5] “Functional characterization of human NBC4 as an electrogenic Na+-HCO cotransporter (NBCe2).”  Virkki L.V.et.al.   11997242
[6] “Expression of the Na+-HCO-3 cotransporter NBC4 in rat kidney and characterization of a novel NBC4 variant.”  Xu J.et.al.   12388414
[7] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[8] “Molecular expression of SLC4-derived Na+-dependent anion transporters in selected human tissues.”  Damkier H.H.et.al.   17715183
[9] “Cloning, characterization and chromosomal assignment of NBC4, a new member of the sodium bicarbonate cotransporter family.”  Pushkin A.et.al.   10978526
[10] “Two C-terminal variants of NBC4, a new member of the sodium bicarbonate cotransporter family: cloning, characterization, and localization.”  Pushkin A.et.al.   11087115
[11] “Genomic organization of the DCTN1-SLC4A5 locus encoding both NBC4 and p150(Glued).”  Pushkin A.et.al.   12063394
[12] “Functional characterization of NBC4: a new electrogenic sodium-bicarbonate cotransporter.”  Sassani P.et.al.   11788353
[13] “Functional characterization of human NBC4 as an electrogenic Na+-HCO cotransporter (NBCe2).”  Virkki L.V.et.al.   11997242
[14] “Expression of the Na+-HCO-3 cotransporter NBC4 in rat kidney and characterization of a novel NBC4 variant.”  Xu J.et.al.   12388414
[15] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[16] “Molecular expression of SLC4-derived Na+-dependent anion transporters in selected human tissues.”  Damkier H.H.et.al.   17715183

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MKVKEEKAGV GKLDHTNHRR RFPDQKECPP IHIGLPVPTY PQRKTDQKGH LSGLQKVHWG 
61:	LRPDQPQQEL TGPGSGASSQ DSSMDLISRT RSPAAEQLQD ILGEEDEAPN PTLFTEMDTL 
121:	QHDGDQMEWK ESARWIKFEE KVEEGGERWS KPHVSTLSLH SLFELRTCLQ TGTVLLDLDS 
181:	GSLPQIIDDV IEKQIEDGLL RPELRERVSY VLLRRHRHQT KKPIHRSLAD IGKSVSTTNR 
241:	SPARSPGAGP SLHHSTEDLR MRQSANYGRL CHAQSRSMND ISLTPNTDQR KNKFMKKIPK 
301:	DSEASNVLVG EVDFLDQPFI AFVRLIQSAM LGGVTEVPVP TRFLFILLGP SGRAKSYNEI 
361:	GRAIATLMVD DLFSDVAYKA RNREDLIAGI DEFLDEVIVL PPGEWDPNIR IEPPKKVPSA 
421:	DKRKSVFSLA ELGQMNGSVG GGGGAPGGGN GGGGGGGSGG GAGSGGAGGT SSGDDGEMPA 
481:	MHEIGEELIW TGRFFGGLCL DIKRKLPWFP SDFYDGFHIQ SISAILFIYL GCITNAITFG 
541:	GLLGDATDNY QGVMESFLGT AMAGSLFCLF SGQPLIILSS TGPILIFEKL LFDFSKGNGL 
601:	DYMEFRLWIG LHSAVQCLIL VATDASFIIK YITRFTEEGF STLISFIFIY DAIKKMIGAF 
661:	KYYPINMDFK PNFITTYKCE CVAPDTVNTT VFNASAPLAP DTNASLYNLL NLTALDWSLL 
721:	SKKECLSYGG RLLGNSCKFI PDLALMSFIL FFGTYSMTLT LKKFKFSRYF PTKVRALVAD 
781:	FSIVFSILMF CGIDACFGLE TPKLHVPSVI KPTRPDRGWF VAPFGKNPWW VYPASILPAL 
841:	LVTILIFMDQ QITAVIVNRK ENKLKKAAGY HLDLFWVGIL MALCSFMGLP WYVAATVISI 
901:	AHIDSLKMET ETSAPGEQPQ FLGVREQRVT GIIVFILTGI SVFLAPILKC IPLPVLYGVF 
961:	LYMGVASLNG IQMGTGGSEF KIQKKLTPFW ERCKLFLMPA KHQPDHAFLR HVPLRRIHLF 
1021:	TLVQILCLAV LWILKSTVAA IIFPVMILGL IIVRRLLDFI FSQHDLAWID NILPEKEKKE 
1081:	TDKKRKRKKG AHEDCDEEPQ FPPPSVIKIP MESVQSDPQN GIHCIARKRS SSWSYSL