2.A.34.1.3
Na+/H+ antiporter that extrudes sodium in exchange for external protons, NhaB of 500 aas. Can also extrude lithium in exchange for protons. Km values for Li+ and Na+ of 2.0 mM and 1.3 mM, respectively. The
antiport activity was inhibited by amiloride with a Ki value of 0.04 mM (Kuroda et al. 2004).
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| Accession Number: | Q9I2S5 |
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| Protein Name: | Na(+)/H(+) antiporter NhaB |
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| Length: | 500 |
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| Molecular Weight: | 54234.00 |
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| Species: | Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) [208964] |
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| Number of TMSs: | 14 |
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| Location1 / Topology2 / Orientation3: |
Cell inner membrane1 / Multi-pass membrane protein2 |
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| Substrate |
lithium(1+), sodium(1+), hydron |
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1: MSSPLSQAFA QNFLGHSPRW YKLTVLAFLL LNPLLLWLAG PVTSAWVLVG EFIFTLAMAL
61: KCYPLQPGGL LVLEALLLGL ATPEALYAEL QHNFPVLLLL MFMVAGIYFM KDLLLLLFSR
121: LLLGVRSKTL LSLLFCLLAA LLSAFLDALT VTAVVISVAV AFFAVYHRVA SGQRASEDYD
181: PATDRQVPEL HRAHLEEFRA FLRSLLMHAA VGTALGGVCT LVGEPQNLLI GHEAGWHFVE
241: FFRQVAPVSM PVLAAGLLTC VLLEKSRRFG YGAQLPAAVR QVLAEYAASE SRKRGAQQKA
301: ALLVQALAAL VLIVGLALHV AEVGLIGLLV IVLITAFTGV TDEHQIGRAF QEALPFTALL
361: VVFFAVVAVI HQQHLFTPII QAVLALPAER QPGMLFIANG LLSAISDNVF VATIYITEVK
421: QALDAGHMSR EHFDTLAVAI NTGTNLPSVA TPNGQAAFLF LLTSSIAPLV RLSYGRMVWM
481: ALPYTLVMGG LGWWAVSHWL