2.A.36.6.11
Na+/H+ antiporter, NhaP2 (YcgO; CvrA) of 578 aas and 13 TMSs. Involved in growth at low osmolarity, intracellular K+ maintenance, and volume regulation (Verkhovskaya et al. 2001). Hyposaline xonsiriona induces oxidative stress and disrupts gut microbiome stability
in C. notata, thereby triggering complex physiological and molecular
responses (Kim et al. 2025).
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| Accession Number: | P76007 |
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| Protein Name: | K(+)/H(+) antiporter NhaP2 |
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| Length: | 578 |
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| Molecular Weight: | 62285.00 |
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| Species: | Escherichia coli (strain K12) [83333] |
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| Number of TMSs: | 13 |
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| Location1 / Topology2 / Orientation3: |
Cell inner membrane1 / Multi-pass membrane protein2 |
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| Substrate |
sodium(1+) |
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1: MDATTIISLF ILGSILVTSS ILLSSFSSRL GIPILVIFLA IGMLAGVDGV GGIPFDNYPF
61: AYMVSNLALA IILLDGGMRT QASSFRVALG PALSLATLGV LITSGLTGMM AAWLFNLDLI
121: EGLLIGAIVG STDAAAVFSL LGGKGLNERV GSTLEIESGS NDPMAVFLTI TLIAMIQHHE
181: SNISWMFIVD ILQQFGLGIV IGLGGGYLLL QMINRIALPA GLYPLLALSG GILIFSLTTA
241: LEGSGILAVY LCGFLLGNRP IRNRYGILQN FDGLAWLAQI AMFLVLGLLV NPSDLLPIAI
301: PALILSAWMI FFARPLSVFA GLLPFRGFNL RERVFISWVG LRGAVPIILA VFPMMAGLEN
361: ARLFFNVAFF VVLVSLLLQG TSLSWAAKKA KVVVPPVGRP VSRVGLDIHP ENPWEQFVYQ
421: LSADKWCVGA ALRDLHMPKE TRIAALFRDN QLLHPTGSTR LREGDVLCVI GRERDLPALG
481: KLFSQSPPVA LDQRFFGDFI LEASAKYADV ALIYGLEDGR EYRDKQQTLG EIVQQLLGAA
541: PVVGDQVEFA GMIWTVAEKE DNEVLKIGVR VAEEEAES