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2.A.38.3.2
K+ (high affinity) Na+ -selective (low affinity) uptake symporter, AtHKT1 (does not catalyze recirculation from shoots to roots as proposed by Berthomieu et al., 2003, but mediates Na+ unloading from the xylem sap and thereby protects plant leaves from toxic Na+ over accumulation (Sunarpi et al. 2005). Kato et al. (2007) have reported that AtHKT1 is a Na+ uniporter.

Accession Number:Q84TI7
Protein Name:Sodium transporter HKT1
Length:506
Molecular Weight:57450.00
Species: [3702]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate sodium(1+), potassium(1+)

Cross database links:

RefSeq: NP_567354.1   
Entrez Gene ID: 826623   
Pfam: PF02386   
BioCyc: MetaCyc:MONOMER-14577   
KEGG: ath:AT4G10310   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015079 F:potassium ion transmembrane transporter act...
GO:0006813 P:potassium ion transport
GO:0009651 P:response to salt stress
GO:0006814 P:sodium ion transport
GO:0055085 P:transmembrane transport

References (10)

[1] “The Arabidopsis HKT1 gene homolog mediates inward Na(+) currents in Xenopus laevis oocytes and Na(+) uptake in Saccharomyces cerevisiae.”  Uozumi N.et.al.   10759522
[2] “Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.”  Mayer K.F.X.et.al.   10617198
[3] “Empirical analysis of transcriptional activity in the Arabidopsis genome.”  Yamada K.et.al.   14593172
[4] “Evidence in support of a four transmembrane-pore-transmembrane topology model for the Arabidopsis thaliana Na+/K+ translocating AtHKT1 protein, a member of the superfamily of K+ transporters.”  Kato Y.et.al.   11344270
[5] “AtHKT1 is a salt tolerance determinant that controls Na(+) entry into plant roots.”  Rus A.et.al.   11698666
[6] “Glycine residues in potassium channel-like selectivity filters determine potassium selectivity in four-loop-per-subunit HKT transporters from plants.”  Maeser P.et.al.   11959905
[7] “Altered shoot/root Na+ distribution and bifurcating salt sensitivity in Arabidopsis by genetic disruption of the Na+ transporter AtHKT1.”  Maeser P.et.al.   12417304
[8] “Functional analysis of AtHKT1 in Arabidopsis shows that Na(+) recirculation by the phloem is crucial for salt tolerance.”  Berthomieu P.et.al.   12727868
[9] “AtHKT1 facilitates Na+ homeostasis and K+ nutrition in planta.”  Rus A.et.al.   15347798
[10] “Microarray-based rapid cloning of an ion accumulation deletion mutant in Arabidopsis thaliana.”  Gong J.-M.et.al.   15486089

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MDRVVAKIAK IRSQLTKLRS LFFLYFIYFL FFSFLGFLAL KITKPRTTSR PHDFDLFFTS 
61:	VSAITVSSMS TVDMEVFSNT QLIFLTILMF LGGEIFTSFL NLYVSYFTKF VFPHNKIRHI 
121:	LGSYNSDSSI EDRCDVETVT DYREGLIKID ERASKCLYSV VLSYHLVTNL VGSVLLLVYV 
181:	NFVKTARDVL SSKEISPLTF SVFTTVSTFA NCGFVPTNEN MIIFRKNSGL IWLLIPQVLM 
241:	GNTLFPCFLV LLIWGLYKIT KRDEYGYILK NHNKMGYSHL LSVRLCVLLG VTVLGFLIIQ 
301:	LLFFCAFEWT SESLEGMSSY EKLVGSLFQV VNSRHTGETI VDLSTLSPAI LVLFILMMYL 
361:	PPYTLFMPLT EQKTIEKEGG DDDSENGKKV KKSGLIVSQL SFLTICIFLI SITERQNLQR 
421:	DPINFNVLNI TLEVISAYGN VGFTTGYSCE RRVDISDGGC KDASYGFAGR WSPMGKFVLI 
481:	IVMFYGRFKQ FTAKSGRAWI LYPSSS