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| Accession Number: | Q8TAD4 |
| Protein Name: | Znt5 |
| Length: | 765 |
| Molecular Weight: | 84047.00 |
| Species: | Homo sapiens (Human) [9606] |
| Number of TMSs: | 17 |
| Location1 / Topology2 / Orientation3: | Golgi apparatus1 / Multi-pass membrane protein2 |
| Substrate | zinc(2+) |
Cross database links:
| RefSeq: | NP_075053.2 |
|---|---|
| Entrez Gene ID: | 64924 |
| Pfam: | PF01545 |
| OMIM: |
607819 gene |
| KEGG: | hsa:64924 hsa:64924 |
Gene Ontology
GO:0016324
C:apical plasma membrane
GO:0005794
C:Golgi apparatus
GO:0005887
C:integral to plasma membrane
GO:0005624
C:membrane fraction
GO:0030667
C:secretory granule membrane
GO:0008270
F:zinc ion binding
GO:0005385
F:zinc ion transmembrane transporter activity
GO:0006882
P:cellular zinc ion homeostasis
GO:0006824
P:cobalt ion transport
GO:0010155
P:regulation of proton transport
GO:0010043
P:response to zinc ion
GO:0055085
P:transmembrane transport
GO:0006829
P:zinc ion transport
GO:0000139
C:Golgi membrane
GO:0005730
C:nucleolus
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References (19)[1] “Cloning and characterization of a novel mammalian zinc transporter, zinc transporter 5, abundantly expressed in pancreatic beta cells.” Kambe T.et.al. 11904301 [2] “A novel zinc-regulated human zinc transporter, hZTL1, is localized to the enterocyte apical membrane.” Cragg R.A.et.al. 11937503 [3] “Differential regulation of zinc efflux transporters ZnT-1, ZnT-5 and ZnT-7 gene expression by zinc levels: a real-time RT-PCR study.” Devergnas S.et.al. 15276077 [4] “The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.” Clark H.F.et.al. 12975309 [5] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [6] “The full-ORF clone resource of the German cDNA consortium.” Bechtel S.et.al. 17974005 [7] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [8] “Two different zinc transport complexes of cation diffusion facilitator proteins localized in the secretory pathway operate to activate alkaline phosphatases in vertebrate cells.” Suzuki T.et.al. 15994300 [9] “Zinc transporters, ZnT5 and ZnT7, are required for the activation of alkaline phosphatases, zinc-requiring enzymes that are glycosylphosphatidylinositol-anchored to the cytoplasmic membrane.” Suzuki T.et.al. 15525635 [10] “Cloning and characterization of a novel mammalian zinc transporter, zinc transporter 5, abundantly expressed in pancreatic beta cells.” Kambe T.et.al. 11904301 [11] “A novel zinc-regulated human zinc transporter, hZTL1, is localized to the enterocyte apical membrane.” Cragg R.A.et.al. 11937503 [12] “Differential regulation of zinc efflux transporters ZnT-1, ZnT-5 and ZnT-7 gene expression by zinc levels: a real-time RT-PCR study.” Devergnas S.et.al. 15276077 [13] “The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.” Clark H.F.et.al. 12975309 [14] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [15] “The full-ORF clone resource of the German cDNA consortium.” Bechtel S.et.al. 17974005 [16] “The DNA sequence and comparative analysis of human chromosome 5.” Schmutz J.et.al. 15372022 [17] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [18] “Two different zinc transport complexes of cation diffusion facilitator proteins localized in the secretory pathway operate to activate alkaline phosphatases in vertebrate cells.” Suzuki T.et.al. 15994300 [19] “Zinc transporters, ZnT5 and ZnT7, are required for the activation of alkaline phosphatases, zinc-requiring enzymes that are glycosylphosphatidylinositol-anchored to the cytoplasmic membrane.” Suzuki T.et.al. 15525635
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External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MEEKYGGDVL AGPGGGGGLG PVDVPSARLT KYIVLLCFTK FLKAVGLFES YDLLKAVHIV 61: QFIFILKLGT AFFMVLFQKP FSSGKTITKH QWIKIFKHAV AGCIISLLWF FGLTLCGPLR 121: TLLLFEHSDI VVISLLSVLF TSSGGGPAKT RGAAFFIIAV ICLLLFDNDD LMAKMAEHPE 181: GHHDSALTHM LYTAIAFLGV ADHKGGVLLL VLALCCKVGF HTASRKLSVD VGGAKRLQAL 241: SHLVSVLLLC PWVIVLSVTT ESKVESWFSL IMPFATVIFF VMILDFYVDS ICSVKMEVSK 301: CARYGSFPIF ISALLFGNFW THPITDQLRA MNKAAHQEST EHVLSGGVVV SAIFFILSAN 361: ILSSPSKRGQ KGTLIGYSPE GTPLYNFMGD AFQHSSQSIP RFIKESLKQI LEESDSRQIF 421: YFLCLNLLFT FVELFYGVLT NSLGLISDGF HMLFDCSALV MGLFAALMSR WKATRIFSYG 481: YGRIEILSGF INGLFLIVIA FFVFMESVAR LIDPPELDTH MLTPVSVGGL IVNLIGICAF 541: SHAHSHAHGA SQGSCHSSDH SHSHHMHGHS DHGHGHSHGS AGGGMNANMR GVFLHVLADT 601: LGSIGVIVST VLIEQFGWFI ADPLCSLFIA ILIFLSVVPL IKDACQVLLL RLPPEYEKEL 661: HIALEKIQKI EGLISYRDPH FWRHSASIVA GTIHIQVTSD VLEQRIVQQV TGILKDAGVN 721: NLTIQVEKEA YFQHMSGLST GFHDVLAMTK QMESMKYCKD GTYIM