2.A.40.7.7
Guanine/hypoxanthine uptake porter of 455 aas, GhxQ, YgfQ or YgfR. Also takes up mutagens such as 1-methylguanine, 8-azaguanine, 6-thioguanine, and 6-mercaptopurine (Papakostas et al. 2013) and catalyzes dis-C3 (membrane-permeable, cationic fluorescent dye, the carbocyanine diS-C3 efflux (Jindal et al. 2019).
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| Accession Number: | Q46817 |
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| Protein Name: | Putative permease YgfQ |
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| Length: | 455 |
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| Molecular Weight: | 46758.00 |
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| Species: | Escherichia coli (strain K12) [83333] |
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| Number of TMSs: | 13 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MSGDILQTPD APKPQGALDN YFKITARGST VRQEVLAGLT TFLAMVYSVI VVPGMLGKAG
61: FPPAAVFVAT CLVAGFGSLL MGLWANLPMA IGCAISLTAF TAFSLVLGQQ ISVPVALGAV
121: FLMGVIFTAI SVTGVRTWIL RNLPMGIAHG TGIGIGLFLL LIAANGVGMV IKNPIEGLPV
181: ALGAFTSFPV MMSLLGLAVI FGLEKCRVPG GILLVIIAIS IIGLIFDPAV KYHGLVAMPS
241: LTGEDGKSLI FSLDIMGALQ PTVLPSVLAL VMTAVFDATG TIRAVAGQAN LLDKDNQIIN
301: GGKALTSDSV SSIFSGLVGA APAAVYIESA AGTAAGGKTG LTATVVGALF LLILFLSPLS
361: FLIPGYATAP ALMYVGLLML SNVSKLDFND FIDAMAGLVC AVFIVLTCNI VTGIMLGFVT
421: LVVGRVFARE WQKLNIGTVI ITAALVAFYA GGWAI