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| Accession Number: | O00337 |
| Protein Name: | CNT1 aka SLC28A1 |
| Length: | 649 |
| Molecular Weight: | 71584.00 |
| Species: | Homo sapiens (Human) [9606] |
| Number of TMSs: | 15 |
| Location1 / Topology2 / Orientation3: | Membrane1 / Multi-pass membrane protein2 |
| Substrate | cytidine, pyrimidine, adenosine, uridine, thymidine, zalcitabine, zidovudine |
Cross database links:
| RefSeq: | NP_004204.3 NP_964014.1 |
|---|---|
| Entrez Gene ID: | 9154 |
| Pfam: | PF07670 PF07662 PF01773 |
| OMIM: |
606207 gene |
| KEGG: | hsa:9154 hsa:9154 |
Gene Ontology
GO:0005887
C:integral to plasma membrane
GO:0005624
C:membrane fraction
GO:0001882
F:nucleoside binding
GO:0005415
F:nucleoside:sodium symporter activity
GO:0006139
P:nucleobase, nucleoside, nucleotide and nucl...
GO:0015858
P:nucleoside transport
GO:0005337
F:nucleoside transmembrane transporter activity
GO:0006139
P:nucleobase-containing compound metabolic process
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References (10)[1] “Molecular cloning and functional expression of cDNAs encoding a human Na+-nucleoside cotransporter (hCNT1).” Ritzel M.W.L.et.al. 9124315 [2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [3] “Analysis of the DNA sequence and duplication history of human chromosome 15.” Zody M.C.et.al. 16572171 [4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [5] “Identification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na(+) nucleoside cotransporters hCNT1 and hCNT2.” Loewen S.K.et.al. 10455109 [6] “Molecular cloning and functional expression of cDNAs encoding a human Na+-nucleoside cotransporter (hCNT1).” Ritzel M.W.L.et.al. 9124315 [7] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [8] “Analysis of the DNA sequence and duplication history of human chromosome 15.” Zody M.C.et.al. 16572171 [9] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [10] “Identification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na(+) nucleoside cotransporters hCNT1 and hCNT2.” Loewen S.K.et.al. 10455109
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External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MENDPSRRRE SISLTPVAKG LENMGADFLE SLEEGQLPRS DLSPAEIRSS WSEAAPKPFS 61: RWRNLQPALR ARSFCREHMQ LFRWIGTGLL CTGLSAFLLV ACLLDFQRAL ALFVLTCVVL 121: TFLGHRLLKR LLGPKLRRFL KPQGHPRLLL WFKRGLALAA FLGLVLWLSL DTSQRPEQLV 181: SFAGICVFVA LLFACSKHHC AVSWRAVSWG LGLQFVLGLL VIRTEPGFIA FEWLGEQIRI 241: FLSYTKAGSS FVFGEALVKD VFAFQVLPII VFFSCVISVL YHVGLMQWVI LKIAWLMQVT 301: MGTTATETLS VAGNIFVSQT EAPLLIRPYL ADMTLSEVHV VMTGGYATIA GSLLGAYISF 361: GIDATSLIAA SVMAAPCALA LSKLVYPEVE ESKFRREEGV KLTYGDAQNL IEAASTGAAI 421: SVKVVANIAA NLIAFLAVLD FINAALSWLG DMVDIQGLSF QLICSYILRP VAFLMGVAWE 481: DCPVVAELLG IKLFLNEFVA YQDLSKYKQR RLAGAEEWVG DRKQWISVRA EVLTTFALCG 541: FANFSSIGIM LGGLTSMVPQ RKSDFSQIVL RALFTGACVS LVNACMAGIL YMPRGAEVDC 601: MSLLNTTLSS SSFEIYQCCR EAFQSVNPEF SPEALDNCCR FYNHTICAQ