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|---|---|
| Accession Number: | O43868 |
| Protein Name: | CNT2 aka SLC28A2 |
| Length: | 658 |
| Molecular Weight: | 71926.00 |
| Species: | Homo sapiens (Human) [9606] |
| Number of TMSs: | 11 |
| Location1 / Topology2 / Orientation3: | Membrane1 / Multi-pass membrane protein2 |
| Substrate | sodium(1+), 7H-purine, uridine |
Cross database links:
| RefSeq: | NP_004203.2 |
|---|---|
| Entrez Gene ID: | 9153 |
| Pfam: | PF07670 PF07662 PF01773 |
| OMIM: |
606208 gene |
| KEGG: | hsa:9153 hsa:9153 |
Gene Ontology
GO:0005887
C:integral to plasma membrane
GO:0005624
C:membrane fraction
GO:0001882
F:nucleoside binding
GO:0005415
F:nucleoside:sodium symporter activity
GO:0015211
F:purine nucleoside transmembrane transporter...
GO:0006139
P:nucleobase, nucleoside, nucleotide and nucl...
GO:0015860
P:purine nucleoside transport
GO:0015211
F:purine nucleoside transmembrane transporter activity
GO:0006139
P:nucleobase-containing compound metabolic process
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References (14)[1] “Na+-dependent purine nucleoside transporter from human kidney: cloning and functional characterization.” Wang J.et.al. 9435697 [2] “Molecular cloning, functional expression and chromosomal localization of a cDNA encoding a human Na+/nucleoside cotransporter (hCNT2) selective for purine nucleosides and uridine.” Ritzel M.W.L.et.al. 10087507 [3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [5] “Identification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na(+) nucleoside cotransporters hCNT1 and hCNT2.” Loewen S.K.et.al. 10455109 [6] “Genetic analysis and functional characterization of polymorphisms in the human concentrative nucleoside transporter, CNT2.” Owen R.P.et.al. 15861032 [7] “Identification and functional analysis of variants in the human concentrative nucleoside transporter 2, hCNT2 (SLC28A2) in Chinese, Malays and Indians.” Li L.et.al. 17700367 [8] “Na+-dependent purine nucleoside transporter from human kidney: cloning and functional characterization.” Wang J.et.al. 9435697 [9] “Molecular cloning, functional expression and chromosomal localization of a cDNA encoding a human Na+/nucleoside cotransporter (hCNT2) selective for purine nucleosides and uridine.” Ritzel M.W.L.et.al. 10087507 [10] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [11] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [12] “Identification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na(+) nucleoside cotransporters hCNT1 and hCNT2.” Loewen S.K.et.al. 10455109 [13] “Genetic analysis and functional characterization of polymorphisms in the human concentrative nucleoside transporter, CNT2.” Owen R.P.et.al. 15861032 [14] “Identification and functional analysis of variants in the human concentrative nucleoside transporter 2, hCNT2 (SLC28A2) in Chinese, Malays and Indians.” Li L.et.al. 17700367
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External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MEKASGRQSI ALSTVETGTV NPGLELMEKE VEPEGSKRTD AQGHSLGDGL GPSTYQRRSR 61: WPFSKARSFC KTHASLFKKI LLGLLCLAYA AYLLAACILN FQRALALFVI TCLVIFVLVH 121: SFLKKLLGKK LTRCLKPFEN SRLRLWTKWV FAGVSLVGLI LWLALDTAQR PEQLIPFAGI 181: CMFILILFAC SKHHSAVSWR TVFSGLGLQF VFGILVIRTD LGYTVFQWLG EQVQIFLNYT 241: VAGSSFVFGD TLVKDVFAFQ ALPIIIFFGC VVSILYYLGL VQWVVQKVAW FLQITMGTTA 301: TETLAVAGNI FVGMTEAPLL IRPYLGDMTL SEIHAVMTGG FATISGTVLG AFIAFGVDAS 361: SLISASVMAA PCALASSKLA YPEVEESKFK SEEGVKLPRG KERNVLEAAS NGAVDAIGLA 421: TNVAANLIAF LAVLAFINAA LSWLGELVDI QGLTFQVICS YLLRPMVFMM GVEWTDCPMV 481: AEMVGIKFFI NEFVAYQQLS QYKNKRLSGM EEWIEGEKQW ISVRAEIITT FSLCGFANLS 541: SIGITLGGLT SIVPHRKSDL SKVVVRALFT GACVSLISAC MAGILYVPRG AEADCVSFPN 601: TSFTNRTYET YMCCRGLFQS TSLNGTNPPS FSGPWEDKEF SAMALTNCCG FYNNTVCA