2.A.41.2.7
Broad specificity nucleoside:H+ symporter (1:1 stoichiometry). Adenosine, uridine, inosine, and guanosine are transported but not cytidine, thymidine or the nucleobase hypoxanthine (Km range: 15-65 μM). Purine and uridine nucleoside drug analogues including cordycepin (3'-deoxyadenosine) are substrates.
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| Accession Number: | Q874I3 |
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| Protein Name: | H+/nucleoside cotransporter aka CNT |
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| Length: | 608 |
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| Molecular Weight: | 67722.00 |
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| Species: | Candida albicans (Yeast) [5476] |
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| Number of TMSs: | 12 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
hydron, nucleoside |
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1: MVSPSTDKAP SIVELTPETY QQDVSSDSID LESGTKKLQN ESALQSHEYT TNIDETSSSN
61: TASKLTYIQK LKIRFPYYRL AIDIFIGCFF TAWWLSIVIQ PKHRHQWLIP TVIWGMIMVR
121: LITWHIKILP WLLNKVKIVW DFFTGYVYKV LSKKYQRLIT GAVITVGVIL LGTFVPSETE
181: YSKRKDRAIS FFGCIVAIFL LFVTSKAPSK INWNAVIGGM LMQFIIALFV LRTKCGYDVF
241: NFISTLAREL LGFAKDGVAF LTNKDVSQLG MFFFTVLPSV AFFVAFIHIW YYFGVIQWAI
301: RKFAYFFFWT LRVSGAEAIT AAASPFIGIG ESAILIKDLM PYLTKAELHQ IMTSGFSTIS
361: GAVLVGYIGL GLNPQALVSS CVMSIPASLA VSKLRYPELE NPISSGTVMI PKVEDSEAAR
421: EKSKDEPQNV LQAFSNGATL GLRIAGTMMI QCMCIIGLVA LCNGILTWFG NYWNIDHLTL
481: ELILSYIFYP IGFLLGTPRN EILLVNKLIA YKFIQNEYVA YNLLTNEAPY NEMSKRGTLI
541: ATYACCGFAN LGSLGITLGV LNTLTNNSRA KDISSSIISA LFCGAIATML SAAIAGMVMH
601: DLNTFHIN