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2.A.47.1.15
Solute carrier family 13 member 3, SLC13A3 (Na+/dicarboxylate cotransporter 3; NaDC-3; hNaDC3; SDCT2) (Sodium-dependent high-affinity dicarboxylate transporter 2) of 602 aas with about 16 TMSs in a possible 4 - 7 + 9 or 10 TMS arrangement.  (Bergeron et al. 2013; Schlosser et al. 2023). The SLC13A3 gene encodes a plasma membrane-localized Na+/dicarboxylate cotransporter 3 (NaDC3) primarily expressed in the kidney, astrocytes and choroid plexus. In addition to three Na+ ions, it brings four to six carbon dicarboxylates into the cytosol (Hussain et al. 2023).  Patients with acute reversible leukoencephalopathy and α-ketoglutarate accumulation (ARLIAK) carry pathogenic mutations in the SLC13A3 gene (Hussain et al. 2023).

Accession Number:Q8WWT9
Protein Name:Solute carrier family 13 member 3
Length:602
Molecular Weight:66841.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate sodium(1+), dicarboxylic acid dianion

Cross database links:

Entrez Gene ID: 64849   
Pfam: PF00939   
KEGG: hsa:64849   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005624 C:membrane fraction
GO:0005886 C:plasma membrane
GO:0015137 F:citrate transmembrane transporter activity
GO:0015362 F:high affinity sodium:dicarboxylate symporter activity
GO:0015183 F:L-aspartate transmembrane transporter activity
GO:0015141 F:succinate transmembrane transporter activity
GO:0055085 P:transmembrane transport

References (6)

[1] “Structure, function, and genomic organization of human Na(+)-dependent high-affinity dicarboxylate transporter.”  Wang H.et.al.   10794676
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “The DNA sequence and comparative analysis of human chromosome 20.”  Deloukas P.et.al.   11780052
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “The full-ORF clone resource of the German cDNA consortium.”  Bechtel S.et.al.   17974005
[6] “Membrane topology structure of human high-affinity, sodium-dependent dicarboxylate transporter.”  Bai X.Y.et.al.   17426067

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MAALAAAAKK VWSARRLLVL LFTPLALLPV VFALPPKEGR CLFVILLMAV YWCTEALPLS 
61:	VTALLPIVLF PFMGILPSNK VCPQYFLDTN FLFLSGLIMA SAIEEWNLHR RIALKILMLV 
121:	GVQPARLILG MMVTTSFLSM WLSNTASTAM MLPIANAILK SLFGQKEVRK DPSQESEENT 
181:	AAVRRNGLHT VPTEMQFLAS TEAKDHPGET EVPLDLPADS RKEDEYRRNI WKGFLISIPY 
241:	SASIGGTATL TGTAPNLILL GQLKSFFPQC DVVNFGSWFI FAFPLMLLFL LAGWLWISFL 
301:	YGGLSFRGWR KNKSEIRTNA EDRARAVIRE EYQNLGPIKF AEQAVFILFC MFAILLFTRD 
361:	PKFIPGWASL FNPGFLSDAV TGVAIVTILF FFPSQRPSLK WWFDFKAPNT ETEPLLTWKK 
421:	AQETVPWNII LLLGGGFAMA KGCEESGLSV WIGGQLHPLE NVPPALAVLL ITVVIAFFTE 
481:	FASNTATIII FLPVLAELAI RLRVHPLYLM IPGTVGCSFA FMLPVSTPPN SIAFASGHLL 
541:	VKDMVRTGLL MNLMGVLLLS LAMNTWAQTI FQLGTFPDWA DMYSVNVTAL PPTLANDTFR 
601:	TL