2.A.47.2.4
Contractile vacuole phosphate:Na+ symporter of 727 aas and 12 TMSs, Pho91 (Pho90; Pho87). Has an N-terminal SPX domain and a C-terminal anion permease domain. Plays an indirect role in pyrophosphate and oligophosphate synthesis (Jimenez and Docampo 2015). Pyrophosphate stimulates the phosphate-sodium symporter of Trypanosoma brucei acidocalcisomes and Saccharomyces cerevisiae vacuoles (Potapenko et al. 2019).
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| Accession Number: | Q4DX24 |
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| Protein Name: | Sodium/sulphate symporter, putative |
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| Length: | 727 |
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| Molecular Weight: | 80492.00 |
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| Species: | Trypanosoma cruzi (strain CL Brener) [353153] |
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| Number of TMSs: | 12 |
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| Substrate |
sodium(1+), phosphate(3-) |
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1: MKFGKRFQEE MVEQWRESYV NYKALKQLIY HSELSGVEFS RDFFAMVTEE LEKAEGLFQD
61: LLDELQQSHD ELLEQDPDLP VMNPIRTLRF YRKRVHRDTR STNGSGDSEV FDSSRASSTV
121: DPEPGRRGCI PSVVKSLFLL IIGDSHKRAF DEHAPRAKFA EWHSSAHKLQ HFAELNLEAV
181: RKAAKKLKKH RRREGDFTIA IEAEINRSRL VTLMPRLRSL MADIDSDYER KFGDSLDQYK
241: NVAMQQAYHA KWQFVFLSAA LFCLLMFLPI LSEHPPAHNC VALFGLIVSL WITEAIPFFC
301: TAMLIPIVAV PLGIIADPHT NEVANSTVAS GIILGKVMDH VQILVLGGLT IGKALARTNL
361: EAYAATALYR LTAHRPPFYL LGVMLWSGVL CAFVSNVAAP LLVLGVIQRT LWEFPEDTEA
421: PHGILLGLAF ACNIGGMLSP IASPQNAVAM NVLRFHSVSF AAWIAVALPI VLFSIVAAWA
481: IILVVWKPFK DVKGIPLHVV STESGKDTRV TDRVVVVVVS LITIILWIIS PDVLFGDTGV
541: VALIPIVVFF GTGILAKEDF NTLSWHLMFL LAGGNMLGLC AHDSKMLDIL AHSMHGTLVS
601: QPPYLTFVLV ILVVALATTF VSHTVSAMIL LPIIAKIGFL LPKHEGILSV TPATLVMLSA
661: LMCSGAMAFP ISSFPNVNSL LAEDSTGQPY LKAKDFLFCG TLITLLFLFC LVTWMIPLAY
721: VVLEGFN