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2.A.47.5.2
Dicarboxylate (succinate, fumarate, malate) transporter, vcINDY.  The 3-d structure is known to 3.2 Å resolution with citrate and Na+ bound (Mancusso et al. 2012).  INDY may also transport citrate, glutamate and sulfate with low affinity.  It can use Na+ or Li+ as the cotransported cation.  MtrF (TC# 2.A.68.1.2) and YdaH (TC# 2.A.68.1.4) have been shown to have similar 3-d folds as vcINDY (Vergara-Jaque et al. 2015), confirming the assignment of these two families to the same superfamily (Prakash et al. 2003). Solvent accessibility studies suggested differential substrate effects in a multistep mechanism where Na+ binding drives a conformational change, involving rearrangement of the substrate binding site-associated re-entrant hairpin loops (Sampson et al. 2020).

Accession Number:Q9KNE0
Protein Name:Transporter, NadC family
Length:462
Molecular Weight:49569.00
Species:Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) [243277]
Number of TMSs:15
Substrate lithium(1+), sodium(1+), fumarate(2-), citrate salt, glutamate(2-), malate(2-), succinate(2-)

Cross database links:

Structure:
4F35   5UL7   5UL9   5ULD   5ULE     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNRNDSVPLP TNTREWFLHR NSLIVLADVA LFLALYHFLP FEHNVVLGIS MLAFIAVLWL 
61:	TEALHVTVTA ILVPVMAVFF GIFETQAALN NFANSIIFLF LGGFALAAAM HHQGLDKVIA 
121:	DKVLAMAQGK MSVAVFMLFG VTALLSMWIS NTATAAMMLP LVLGVLSKVD ADKQRSTYVF 
181:	VLLGVAYSAS IGGIATLVGS PPNAIAAAEV GLSFTDWMKF GLPTAMMMLP MAIAILYFLL 
241:	KPTLNGMFEL DRAPVNWDKG KVVTLGIFGL TVFLWIFSSP INAALGGFKS FDTLVALGAI 
301:	LMLSFARVVH WKEIQKTADW GVLLLFGGGL CLSNVLKQTG TSVFLANALS DMVSHMGIFV 
361:	VILVVATFVV FLTEFASNTA SAALLIPVFA TVAEAFGMSP VLLSVLIAVA ASCAFMLPVA 
421:	TPPNAIVFAS GHIKQSEMMR VGLYLNIACI GLLTAIAMLF WQ