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Accession Number: | Q9BZV2 |
Protein Name: | Thiamine transporter 2 |
Length: | 496 |
Molecular Weight: | 55665.00 |
Species: | Homo sapiens (Human) [9606] |
Number of TMSs: | 12 |
Location1 / Topology2 / Orientation3: | Membrane1 / Multi-pass membrane protein2 |
Substrate | thiamine(1+) |
Cross database links:
Entrez Gene ID: | 80704 |
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Pfam: | PF01770 |
KEGG: | hsa:80704 hsa:80704 |
Gene Ontology
GO:0016021
C:integral to membrane
GO:0005886
C:plasma membrane
GO:0005542
F:folic acid binding
GO:0008518
F:reduced folate carrier activity
GO:0015403
F:thiamine uptake transmembrane transporter activity
GO:0042723
P:thiamine-containing compound metabolic process
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References (14)[1] “Identification and characterization of the human and mouse SLC19A3 gene: a novel member of the reduced folate family of micronutrient transporter genes.” Eudy J.D.et.al. 11136550 [2] “Generation and annotation of the DNA sequences of human chromosomes 2 and 4.” Hillier L.W.et.al. 15815621 [3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [4] “SLC19A3 encodes a second thiamine transporter ThTr2.” Rajgopal A.et.al. 11731220 [5] “SLC19: the folate/thiamine transporter family.” Ganapathy V.et.al. 14770311 [6] “Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.” Chen R.et.al. 19159218 [7] “Biotin-responsive basal ganglia disease maps to 2q36.3 and is due to mutations in SLC19A3.” Zeng W.-Q.et.al. 15871139 [8] “Identification and characterization of the human and mouse SLC19A3 gene: a novel member of the reduced folate family of micronutrient transporter genes.” Eudy J.D.et.al. 11136550 [9] “Generation and annotation of the DNA sequences of human chromosomes 2 and 4.” Hillier L.W.et.al. 15815621 [10] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 |
External Searches:
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Analyze:
Predict TMSs (Predict number of transmembrane segments) | ||||
FASTA formatted sequence |
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1: MDCYRTSLSS SWIYPTVILC LFGFFSMMRP SEPFLIPYLS GPDKNLTSAE ITNEIFPVWT 61: YSYLVLLLPV FVLTDYVRYK PVIILQGISF IITWLLLLFG QGVKTMQVVE FFYGMVTAAE 121: VAYYAYIYSV VSPEHYQRVS GYCRSVTLAA YTAGSVLAQL LVSLANMSYF YLNVISLASV 181: SVAFLFSLFL PMPKKSMFFH AKPSREIKKS SSVNPVLEET HEGEAPGCEE QKPTSEILST 241: SGKLNKGQLN SLKPSNVTVD VFVQWFQDLK ECYSSKRLFY WSLWWAFATA GFNQVLNYVQ 301: ILWDYKAPSQ DSSIYNGAVE AIATFGGAVA AFAVGYVKVN WDLLGELALV VFSVVNAGSL 361: FLMHYTANIW ACYAGYLIFK SSYMLLITIA VFQIAVNLNV ERYALVFGIN TFIALVIQTI 421: MTVIVVDQRG LNLPVSIQFL VYGSYFAVIA GIFLMRSMYI TYSTKSQKDV QSPAPSENPD 481: VSHPEEESNI IMSTKL