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2.A.5.3.2 Zn²⁺ uptake transporter, Zip1 (abundantly expressed; involved in zinc homeostasis rather than acquisition of dietary Zn²⁺) (Gaither and Eide, 2000). Mouse Zip1, 2 and 3 play important noncompensatory roles under conditions of zinc deficiency (Kambe et al. 2008).
Accession Number:	Q9NY26
Protein Name:	Zinc transporter ZIP1
Length:	324
Molecular Weight:	34250.00
Species:	Homo sapiens (Human) [9606]
Number of TMSs:	8
Location¹ / Topology² / Orientation³:	Cell membrane¹ / Multi-pass membrane protein²
Substrate	zinc(2+)

RefSeq:	NP_055252.2
Entrez Gene ID:	27173
Pfam:	PF02535
OMIM:	604740 gene
KEGG:	hsa:27173 hsa:27173
Gene Ontology GO:0005789 C:endoplasmic reticulum membrane GO:0016021 C:integral to membrane GO:0005624 C:membrane fraction GO:0005886 C:plasma membrane GO:0015674 P:di-, tri-valent inorganic cation transport GO:0055085 P:transmembrane transport GO:0006829 P:zinc ion transport GO:0022890 F:inorganic cation transmembrane transporter activity GO:0005385 F:zinc ion transmembrane transporter activity GO:0071577 P:zinc ion transmembrane transport
References (14) [1] “Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex.” Lioumi M.et.al. 10610721 [2] “Differential subcellular localization of hZip1 in adherent and non-adherent cells.” Milon B.et.al. 11696349 [3] “Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.” Lai C.-H.et.al. 10810093 [4] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [6] “The human ZIP1 transporter mediates zinc uptake in human K562 erythroleukemia cells.” Gaither L.A.et.al. 11301334 [7] “Human ZIP1 is a major zinc uptake transporter for the accumulation of zinc in prostate cells.” Franklin R.B.et.al. 12888280 [8] “Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex.” Lioumi M.et.al. 10610721 [9] “Differential subcellular localization of hZip1 in adherent and non-adherent cells.” Milon B.et.al. 11696349 [10] “Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.” Lai C.-H.et.al. 10810093 [11] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [12] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [13] “The human ZIP1 transporter mediates zinc uptake in human K562 erythroleukemia cells.” Gaither L.A.et.al. 11301334 [14] “Human ZIP1 is a major zinc uptake transporter for the accumulation of zinc in prostate cells.” Franklin R.B.et.al. 12888280

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FASTA formatted sequence

1:	MGPWGEPELL VWRPEAVASE PPVPVGLEVK LGALVLLLVL TLLCSLVPIC VLRRPGANHE 
61:	GSASRQKALS LVSCFAGGVF LATCLLDLLP DYLAAIDEAL AALHVTLQFP LQEFILAMGF 
121:	FLVLVMEQIT LAYKEQSGPS PLEETRALLG TVNGGPQHWH DGPGVPQASG APATPSALRA 
181:	CVLVFSLALH SVFEGLAVGL QRDRARAMEL CLALLLHKGI LAVSLSLRLL QSHLRAQVVA 
241:	GCGILFSCMT PLGIGLGAAL AESAGPLHQL AQSVLEGMAA GTFLYITFLE ILPQELASSE 
301:	QRILKVILLL AGFALLTGLL FIQI

2.A.5.3.2
Zn²⁺ uptake transporter, Zip1 (abundantly expressed; involved in zinc homeostasis rather than acquisition of dietary Zn²⁺) (Gaither and Eide, 2000). Mouse Zip1, 2 and 3 play important noncompensatory roles under conditions of zinc deficiency (Kambe et al. 2008).

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Gene Ontology

References (14)

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2.A.5.3.2Zn2+ uptake transporter, Zip1 (abundantly expressed; involved in zinc homeostasis rather than acquisition of dietary Zn2+) (Gaither and Eide, 2000). Mouse Zip1, 2 and 3 play important noncompensatory roles under conditions of zinc deficiency (Kambe et al. 2008).

Cross database links:

Gene Ontology

References (14)

External Searches:

Analyze:

2.A.5.3.2
Zn²⁺ uptake transporter, Zip1 (abundantly expressed; involved in zinc homeostasis rather than acquisition of dietary Zn²⁺) (Gaither and Eide, 2000). Mouse Zip1, 2 and 3 play important noncompensatory roles under conditions of zinc deficiency (Kambe et al. 2008).