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2.A.5.4.10
Zn2+ transporter, Zip5 (540 aas; 1+3+3 TMSs; processed to a 3+3 TMS protein in the basolateral membrane; it carries out serosal to mucosal transport).  Xenotransplanted human organoids identify transepithelial zinc transports, SLC39A4 and A5, as two mediators of intestinal adaptation (Sampah et al. 2024). Genetic inactivation of SLC39A5 improves liver function and hyperglycemia in obesogenic settings (Chim et al. 2024).

Accession Number:Q6ZMH5
Protein Name:Zinc transporter ZIP5
Length:539
Molecular Weight:56330.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Basolateral cell membrane1 / Multi-pass membrane protein2
Substrate zinc(2+)

Cross database links:

Entrez Gene ID: 283375   
Pfam: PF02535   
KEGG: hsa:283375    hsa:283375   

Gene Ontology

GO:0016323 C:basolateral plasma membrane
GO:0016021 C:integral to membrane
GO:0046873 F:metal ion transmembrane transporter activity
GO:0055085 P:transmembrane transport
GO:0006829 P:zinc ion transport
GO:0034224 P:cellular response to zinc ion starvation

References (6)

[1] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “The mammalian Zip5 protein is a zinc transporter that localizes to the basolateral surface of polarized cells.”  Wang F.et.al.   15322118
[4] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[6] “The mammalian Zip5 protein is a zinc transporter that localizes to the basolateral surface of polarized cells.”  Wang F.et.al.   15322118

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MGSPVSHLLA GFCVWVVLGW VGGSVPNLGP AEQEQNHYLA QLFGLYGENG TLTAGGLARL 
61:	LHSLGLGRVQ GLRLGQHGPL TGRAASPAAD NSTHRPQNPE LSVDVWAGMP LGPSGWGDLE 
121:	ESKAPHLPRG PAPSGLDLLH RLLLLDHSLA DHLNEDCLNG SQLLVNFGLS PAAPLTPRQF 
181:	ALLCPALLYQ IDSRVCIGAP APAPPGDLLS ALLQSALAVL LLSLPSPLSL LLLRLLGPRL 
241:	LRPLLGFLGA LAVGTLCGDA LLHLLPHAQE GRHAGPGGLP EKDLGPGLSV LGGLFLLFVL 
301:	ENMLGLLRHR GLRPRCCRRK RRNLETRNLD PENGSGMALQ PLQAAPEPGA QGQREKNSQH 
361:	PPALAPPGHQ GHSHGHQGGT DITWMVLLGD GLHNLTDGLA IGAAFSDGFS SGLSTTLAVF 
421:	CHELPHELGD FAMLLQSGLS FRRLLLLSLV SGALGLGGAV LGVGLSLGPV PLTPWVFGVT 
481:	AGVFLYVALV DMLPALLRPP EPLPTPHVLL QGLGLLLGGG LMLAITLLEE RLLPVTTEG