2.A.5.4.11
The Zn2+ and Cd2+ uptake porter, ZipB (nonsaturable; electrogenic) (Lin et al. 2010). Water-mediated zinc transport through the ZipB channel sugests an essential role of solvated water molecules in driving zinc coordination dynamics and transmembrane crossing (Gupta et al. 2019). The 3D structure is known for a close ortholog (83% identity) from Bordetella bronchiseptica (Zhang et al. 2023).
|
| Accession Number: | Q2KXZ6 |
|---|
| Protein Name: | Putative zinc transporter |
|---|
| Length: | 278 |
|---|
| Molecular Weight: | 30015.00 |
|---|
| Species: | Bordetella avium (strain 197N) [360910] |
|---|
| Number of TMSs: | 7 |
|---|
| Substrate |
cadmium(2+), zinc(2+) |
|---|
| Entrez Gene ID: |
6266789
|
|---|
| Pfam: |
PF02535
|
|---|
| KEGG: |
bav:BAV2387
|
|---|
GO:0046873
F:metal ion transmembrane transporter activity
|
[1] “Comparison of the genome sequence of the poultry pathogen Bordetella avium with those of B. bronchiseptica, B. pertussis, and B. parapertussis reveals extensive diversity in surface structures associated with host interaction.” Sebaihia M. et.al. 16885469
|
1: MLLLWIILAT IAGGLISVCI AHWLAYRVFV QYLHHMVSLS VGVLLSVALL HLLPEAFESS
61: DADPHQLFGL MLAGLIGFFV LEKISLLRHN HHHEHDGHHH HKGHDRHEAG RGGMLILVGS
121: SLHNLCDGVL VAAAFLTDPL LGVLTAASII VHEVPHKLGD FVVLINAGLE RKRAFGLILF
181: TSLCTAIGGG VGYFLLQEAQ ALVPYVLVIA ASSFLYISVA DLMPQMHERV TLSDAVPQLL
241: LVGVGVAIIY GVTSFMHHEA HSGHVPAGTA VEAGRHRH