2.A.50.1.5
Skinny or Sightless (Rasp, Cmn, Sit, Ski) of 500 aas and 12 TMSs. It is required in hedgehog (hh) expressing cells for
production of appropriate signaling activity in embryos and in the
imaginal precursors of adult tissues. It acts within the secretory pathway
to catalyze N-terminal palmitoylation of Hh; this lipid modification is
required for the embryonic and larval patterning activities of the Hh
signal, but is not required for Wg signaling (Chamoun et al. 2001; Lee and Treisman 2001).
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| Accession Number: | Q9VZU2 |
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| Protein Name: | Protein-cysteine N-palmitoyltransferase Rasp |
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| Length: | 500 |
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| Molecular Weight: | 58106.00 |
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| Species: | Drosophila melanogaster (Fruit fly) [7227] |
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| Number of TMSs: | 12 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MSRLPDRSLL TRCEIFVYFG VYIAYIVVGL YKIYGLRDHI VKEAKFQFPE GWSLYPFSQR
61: RRDDSNDELE NFGDFIVSFW PFYLLHVAVQ GFIRWKRPRL QCLGFIGVCA LALSVNLDWS
121: SMVLLVTLIA SYYIVSLLSL KFLVWLLSAG WILCINVMQK NVWWTDRVGY TEYVLVIVTM
181: SWSVLRGCSY SLSKIGAKQE DLTRYSLVQY LGYAMYFPCL TYGPIISYQR FAARREDEVQ
241: NWLGFVGGVL RSAIWWLVMQ CALHYFYIHY MSRDVRMVEM MDSVFWQHSA GYFMGQFFFL
301: YYVVTYGLGI AFAVQDGIPA PNRPRCIGRI HFYSDMWKYF DEGLYEFLFQ NIYAELCGKR
361: SSAAAKFGAT ALTFAFVFVW HGCYTYVLIW SILNFLCLAA EKVFKTFTAM PEYQRWTQRH
421: LGAVGAQRLY AMLATQLFIP AAFSNVYFIG GQEIGDFLMR GAYLSGVGNY VALCFCSYCF
481: FQCSELLLTK SDGRSKTKTF