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2.A.50.2.6
MBOAT4, GOAT, or OACT4 of 435 aas and 7 - 9 TMSs in a 4 - 6 + 3 TMS arrangement.  It mediates the octanoylation of ghrelin at 'Ser-3',but can use a variety of fatty acids as substrates including octanoic acid, decanoic acid and tetradecanoic acid (Gutierrez et al. 2008). Campaña et al. 2019 reported a structural model of a eukaryotic membrane-bound O-acyltransferase (MBOAT), ghrelin O-acyltransferase (GOAT), which modifies the metabolism-regulating hormone, ghrelin. The proposed structure revealed a strategy for transmembrane protein acylation with catalysis occurring in an internal channel connecting the endoplasmic reticulum (ER) lumen and the cytoplasm (Campaña et al. 2019).  

Accession Number:Q96T53
Protein Name:Ghrelin O-acyltransferase
Length:435
Molecular Weight:49716.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Endoplasmic reticulum membrane1 / Multi-pass membrane protein2
Substrate

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FASTA formatted sequence
1:	MEWLWLFFLH PISFYQGAAF PFALLFNYLC IMDSFSTRAR YLFLLTGGGA LAVAAMGSYA 
61:	VLVFTPAVCA VALLCSLAPQ QVHRWTFCFQ MSWQTLCHLG LHYTEYYLHE PPSVRFCITL 
121:	SSLMLLTQRV TSLSLDICEG KVKAASGGFR SRSSLSEHVC KALPYFSYLL FFPALLGGSL 
181:	CSFQRFQARV QGSSALHPRH SFWALSWRGL QILGLECLNV AVSRVVDAGA GLTDCQQFEC 
241:	IYVVWTTAGL FKLTYYSHWI LDDSLLHAAG FGPELGQSPG EEGYVPDADI WTLERTHRIS 
301:	VFSRKWNQST ARWLRRLVFQ HSRAWPLLQT FAFSAWWHGL HPGQVFGFVC WAVMVEADYL 
361:	IHSFANEFIR SWPMRLFYRT LTWAHTQLII AYIMLAVEVR SLSSLWLLCN SYNSVFPMVY 
421:	CILLLLLAKR KHKCN