2.A.53.3.11
Bicarbonate transporter, DauA (YchM). Also transports dicarboxylic acids including fumarate, aspartate and succinate, and is therefore designated the dicarboxylic acid uptake system A (DauA) (Karinou et al. 2013) It is the only succinate uptake porter at acidic pHs. The STAS domain forms a complex with the acyl carrier protein, ACP and malonyl-ACP, and the complex has been determined by x-ray crystallography (PDB# 3NY7). This complex links bicarbonate and dicarboxylate transport in some way with fatty acid biosynthesis (Moraes and Reithmeier 2012).
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| Accession Number: | P0AFR2 |
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| Protein Name: | Putative sulfate transporter ychM |
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| Length: | 559 |
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| Molecular Weight: | 59429.00 |
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| Species: | Escherichia coli (strain K12) [83333] |
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| Number of TMSs: | 10 |
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| Location1 / Topology2 / Orientation3: |
Cell inner membrane1 / Multi-pass membrane protein2 |
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| Substrate |
fumarate(2-), hydrogencarbonate, aspartate(2-), succinate(2-) |
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1: MNKIFSSHVM PFRALIDACW KEKYTAARFT RDLIAGITVG IIAIPLAMAL AIGSGVAPQY
61: GLYTAAVAGI VIALTGGSRF SVSGPTAAFV VILYPVSQQF GLAGLLVATL LSGIFLILMG
121: LARFGRLIEY IPVSVTLGFT SGIGITIGTM QIKDFLGLQM AHVPEHYLQK VGALFMALPT
181: INVGDAAIGI VTLGILVFWP RLGIRLPGHL PALLAGCAVM GIVNLLGGHV ATIGSQFHYV
241: LADGSQGNGI PQLLPQLVLP WDLPNSEFTL TWDSIRTLLP AAFSMAMLGA IESLLCAVVL
301: DGMTGTKHKA NSELVGQGLG NIIAPFFGGI TATAAIARSA ANVRAGATSP ISAVIHSILV
361: ILALLVLAPL LSWLPLSAMA ALLLMVAWNM SEAHKVVDLL RHAPKDDIIV MLLCMSLTVL
421: FDMVIAISVG IVLASLLFMR RIARMTRLAP VVVDVPDDVL VLRVIGPLFF AAAEGLFTDL
481: ESRLEGKRIV ILKWDAVPVL DAGGLDAFQR FVKRLPEGCE LRVCNVEFQP LRTMARAGIQ
541: PIPGRLAFFP NRRAAMADL